CLEC4A3

CLEC4A3 is a little-characterized member of the CLEC4 (DC-SIGN) subfamily of C-type lectin receptors, defined by a single extracellular carbohydrate-recognition domain and a type II transmembrane topology. Related genes in this cluster reside in the NK-gene-complex region of chromosome 12 and are expressed chiefly in myeloid cells such as macrophages and dendritic cells. Like its better-studied relatives, CLEC4A3 likely participates in glycan recognition at the cell surface, but its ligands and signaling outputs have not been firmly established, and it should be described conservatively. Recombinant CLEC4A3 protein supports exploratory binding studies and annotation of the CLEC4 family in innate-immunity research.