Met
The MET family of receptor tyrosine kinases contains MET, the receptor for hepatocyte growth factor (HGF, scatter factor), and RON (MST1R), the receptor for macrophage-stimulating protein. Both receptors have a characteristic extracellular sema domain, found also in plexins and semaphorins, plus a PSI domain and four immunoglobulin-like repeats. Ligand-induced dimerization triggers kinase activation and a program of invasive growth involving scattering, proliferation, survival, angiogenesis and morphogenesis, essential for embryogenesis, liver regeneration and wound healing. MET is pathologically activated by exon 14 skipping, amplification and activating mutations in lung, gastric, liver and kidney cancers, and by HGF overexpression. MET inhibitors such as cabozantinib, capmatinib and tepotinib are now approved anticancer agents.
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Met Recombinant Proteins (36)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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