RON/MSP receptor
RON, encoded by the MST1R gene and also called the macrophage-stimulating 1 receptor, is the second member of the MET receptor tyrosine kinase family. It is activated by its sole ligand macrophage-stimulating protein (MSP, also hepatocyte growth factor-like protein), which is generated in the liver and circulates in serum. RON is normally expressed on tissue macrophages, epithelial cells and osteoclasts, supporting innate immunity, wound repair and bone remodeling. In cancer, RON is overexpressed or aberrantly activated in breast, colorectal, pancreatic and lung tumors, promoting epithelial-mesenchymal transition, invasion and resistance to EGFR-targeted therapy. Oncogenic RON variants including splice forms are described. Blocking antibodies against RON have been evaluated clinically in solid tumors.
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RON/MSP receptor Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
