Sev
The Sev (Sevenless) family of receptor tyrosine kinases is named after the Drosophila Sevenless receptor, a paradigm of cell-fate specification in which Ras-MAPK signaling from the Sevenless receptor determines the R7 photoreceptor fate in the developing fly eye, with Bride of sevenless (Boss) as transmembrane ligand. In the human kinome, this family is represented solely by ROS1, an orphan receptor kinase with homology to both Sevenless and the ALK family. This evolutionary kinship explains why ROS1 and ALK share highly related kinase domains, resulting in overlapping inhibitor sensitivity, most notably to crizotinib, entrectinib and lorlatinib in ROS1-rearranged tumors.
-
Sev Recombinant Proteins (4)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
