ROS1/ROS
ROS1 encodes an orphan receptor tyrosine kinase and the only human member of the Sevenless (Sev) family. Its large extracellular region has degenerated compared with other receptor kinases and no ligand has been identified. ROS1 is transiently expressed during development in kidney, lung and nervous tissues, where it participates in epithelial differentiation and renal tubule morphogenesis. In disease, ROS1 is principally oncogenic through chromosomal fusions: CD74-ROS1 and numerous other partners generate constitutively active kinases in lung adenocarcinoma, glioblastoma, cholangiocarcinoma and inflammatory myofibroblastic tumors. Because the ROS1 kinase domain closely resembles ALK's, ALK/MET inhibitors such as crizotinib, entrectinib and lorlatinib achieve marked responses in ROS1-rearranged cancers, and ROS1 testing is standard in advanced lung cancer.
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ROS1/ROS Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
