TrkC
TrkC, encoded by the NTRK3 gene, is the specific receptor for neurotrophin-3 (NT-3) and shows the narrowest ligand specificity of the Trk family. It is essential during development for the survival and differentiation of proprioceptive sensory neurons, which convey limb position information to the central nervous system. Ligand binding activates canonical RAS/MAPK, PI3K/AKT, and PLC-gamma cascades, and naturally occurring kinase-insert isoforms extend the receptor's signaling repertoire beyond the canonical pathway. A hallmark of NTRK3 is the ETV6-NTRK3 fusion transcript, the defining lesion of infantile fibrosarcoma and secretory breast carcinoma, which makes TrkC a validated oncogenic target for TRK inhibitors.
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TrkC Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
