A new antibiotic CJ-17,665 from Aspergillus ochraceus

  • J Antibiot (Tokyo). 2001 Nov;54(11):911-6. doi: 10.7164/antibiotics.54.911.
Y Sugie  1 ,  H Hirai ,  T Inagaki ,  M Ishiguro ,  Y J Kim ,  Y Kojima ,  T Sakakibara ,  S Sakemi ,  A Sugiura ,  Y Suzuki ,  L Brennan ,  J Duignan ,  L H Huang ,  J Sutcliffe ,  N Kojima
Affiliations
  • 1. Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. [email protected]
PMID: 11827033 DOI: 10.7164/antibiotics.54.911
Abstract

A new Antibiotic, CJ-17,665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 microg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in natural products.

Products