Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp

  • J Antibiot (Tokyo). 1998 Feb;51(2):123-9. doi: 10.7164/antibiotics.51.123.
M Igarashi  1 ,  T Tsuchida ,  N Kinoshita ,  M Kamijima ,  R Sawa ,  T Sawa ,  H Naganawa ,  M Hamada ,  T Takeuchi ,  K Yamazaki ,  M Ishizuka
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 9544932 DOI: 10.7164/antibiotics.51.123
Abstract

A novel 19-membered macrocyclic lactam Antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study. Cremimycin showed broad antimicrobial activities against Gram-positive bacteria including MRSA.

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