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Art. -Nr.: HY-147526

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RM-581

RM-581, aminosteroid, is an orally active anticancer agent. RM-581 shows anticancer potency against pancreatic, breast, prostate, and ovarian cancers. RM-581 induces endoplasmic reticulum stress and apoptosis via disturbance of cancer cell cholesterol homeostasis. RM-581 can be used for the research of cancer, such as prostate cancer and breast cancer.

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CAS. Nr.: 2086809-59-6
Formel: C₄₀H₄₆N₄O₄
Molecular Weight:646.82

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RM-581 Chemical Structure

CAS. Nr.: 2086809-59-6

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
LAPC4	IC₅₀	0.6 μM Compound: RM-581	Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
LNCaP	IC₅₀	1.2 μM Compound: RM-581	Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
MCF7	IC₅₀	2.6 μM Compound: RM-581	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
OVCAR-3	IC₅₀	5 μM Compound: RM-581	Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
PANC-1	IC₅₀	3.9 μM Compound: RM-581	Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
PC-3	IC₅₀	1.6 μM Compound: RM-581	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
T47D	IC₅₀	0.5 μM Compound: RM-581	Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]

In Vitro

RM-581 (1-5 μM; 3 days) inhibits proliferation of prostate (PC-3, LAPC-4, LNCaP), breast (MCF-7, T-47D), pancreatic (PANC-1), and ovarian (OVCAR-3) cancer cell lines with mean IC₅₀ values ranging from 1.1 μM to 5.0 μM^[1].
RM-581 (10 μM; 1 h) shows moderate metabolic stability in human liver S9 fraction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

LAPC-4, PC-3, LNCaP, MCF-7, T-47D, PANC-1, OVCAR-3
Concentration:

1 μM, 5 μM
Incubation Time:

3 days
Result:

Inhibited cell proliferation with IC₅₀ values: 1.6 μM (PC-3), 0.6 μM (LAPC-4), 1.2 μM (LNCaP), 2.6 μM (MCF-7), 0.5 μM (T-47D), 3.9 μM (PANC-1), 5.0 μM (OVCAR-3).
Exhibited mean IC₅₀ values of 1.1 μM (prostate cancer cells), 1.5 μM (breast cancer cells), 3.9 μM (pancreatic cancer cells), and 5.0 μM (ovarian cancer cells).

In Vivo

RM-581 (60 mg/kg, s.c., 6 days/week for 28 days) exhibits in vivo anticancer efficacy with tumor regression in nude mouse MCF-7 breast cancer xenografts^[2].
RM-581 (10-80 mg/kg, i.g., daily for 5 weeks) inhibits tumor growth in a PANC-1-Luc cell-derived orthotopic xenograft model in nu/nu mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

17β-estradiol (E2)-induced growth of human MCF-7 breast
tumors in ovariectomized (OVX) nude mice^[2]
Dosage:

60 mg/kg
Administration:

s.c., 6 days/week for 28 days
Result:

Reduced tumor size and weight.

Animal Model:

PANC-1-Luc cell-derived orthotopic xenograft model in nu/nu mice^[3]
Dosage:

10, 40, 80 mg/kg
Administration:

i.g., daily for 5 weeks
Result:

Showed inhibited tumor growth of 11, 54 and 76% at 10, 40 and 80 mg/kg, respectively.

Chemical Information

CAS. Nr. 2086809-59-6
Molecular Weight 646.82
Formel C₄₀H₄₆N₄O₄
SMILES

C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(N5CCN(CC5)C([C@H]6N(CCC6)C(C7=NC8=C(C=CC=C8)C=C7)=O)=O)=C(OC)C=C4CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Maltais R, et al. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. Eur J Med Chem. 2020;188:111990. [Content Brief]

[2]. Perreault M, et al. Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. ChemMedChem. 2017 Jan 20;12(2):177-182. [Content Brief]

[3]. Poirier D, et al. A potent aminosteroid (RM-581) that inhibits orally in mice the tumor growth in an orthotopic xenograft pancreatic cancer model[J]. Cancer Research, 2025, 85(8_Supplement_1): 5639-5639.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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