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United States

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Art. -Nr.: HY-P4096B

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scHAP-1

scHAP-1 is a scrambled HAP-1 peptide, and HAP-1 is a synovial homing peptide. After amino acid sequence scrambling, scHAP-1 still specifically binds to human and rabbit fibroblast-like synoviocytes (FLS), while showing extremely weak binding to human umbilical vein endothelial cells, which proves that it remains an effective FLS-targeting ligand. scHAP-1 can be used in studies related to rheumatoid arthritis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₆₀H₉₀N₁₈O₁₇
Molecular Weight:1335.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

scHAP-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

Animal Model:

Wistar rats (female; adjuvant-induced arthritis model)^[1]
Dosage:

0.5 mg drug/0.5 ml/250 g rat/day
Administration:

i.v.; two consecutive days
Result:

Showed a 9-fold increase in fluorescence signal in arthritic joints compared to unaffected joints in the same animals at 3 hours post-injection.

Chemical Information

Molecular Weight 1335.47
Formel C₆₀H₉₀N₁₈O₁₇
Sequence

Ala-Leu-Ser-Gln-Ala-Phe-Arg-His-Ala-Phe-Thr-Ser
Sequence Shortening

ALSQAFRHAFTS
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Vanniasinghe AS, et al. Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clin Immunol. 2014;151(1):43-54. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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