Art. -Nr.: HY-17494A

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Timolol hemihydrate

Name: Timolol hemihydrate
Brand: MedChemExpress
SKU: HY-17494A
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(Synonyms: (S)-L-714,465 hemihydrate; MK 950 hemihydrate)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect.

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CAS. Nr.: 91524-16-2
Formel: C₁₃H₂₄N₄O₃S.1/2H₃O
Molecular Weight:325.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Timolol hemihydrate Chemical Structure

CAS. Nr.: 91524-16-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

β adrenergic receptor

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Timolol (hemihydrate) can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol (hemihydrate) can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Timolol (hemihydrate) (5 mg/kg daily for 12-week) has a cardioprotective effect via inhibition of ERS response in diabetic rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats^[3].
Dosage:

5 mg/kg
Administration:

Timolol (5 mg/kg daily for 12-week)
Result:

Showed cardioprotective effect.

Chemical Information

CAS. Nr. 91524-16-2
Molecular Weight 325.43
Formel C₁₃H₂₄N₄O₃S.1/2H₃O
SMILES

O[C@@H](CNC(C)(C)C)COC1=NSN=C1N2CCOCC2.[1/2H2O]
Synonyms

(S)-L-714,465 hemihydrate; MK 950 hemihydrate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

All Cell Proliferation/Viability AssayIn Vivo Efficacy StudyCell Imaging/StainingHistological Imaging/StainingIFWB

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Journal Impact Factor

Adv Mater

Colloid-Forming Prodrug-Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection. [Abstract]

2025 Feb;37(8):e2419306. PMID: 39763100

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Feb;37(8):e2419306. [Abstract]

Live-cell percentages were assessed by calcein-AM and Hoechst staining in hTCEpi cells after treatment with Timolol maleate ((S)-Timolol Maleate; 0.137% w/v; 24 h). The Timolol maleate group showed a significantly lower percentage of live cells.

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Feb;37(8):e2419306. [Abstract]

IOP was monitored over 24 h and 56 d in rats after a single subconjunctival injection of soluble Timolol maleate ((S)-Timolol Maleate; 0.137% w/v, 30 μL). Timolol maleate significantly reduced IOP at 6 h, but the effect was no longer significant at 24 h.
Adv Funct Mater

2026 Jun 11.

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Jun 11.

IOP was monitored in New Zealand white rabbits after a single subconjunctival injection of (S)-timolol maleate solution or DSGS-T (DSGS loaded with (S)-timolol maleate) (Timolol maleate; both 1 mg/mL, 0.1 mL per eye; single dose). Timolol maleate and DSGS-T significantly decreased IOP compared with saline.
Protein Cell

Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. [Abstract]

2019 Mar;10(3):178-195. PMID: 29542010

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Protein Cell. 2019 Mar;10(3):178-195. [Abstract]

Cell viability was assessed in Huh7.5.1 cells after treatment with (S)-timolol maleate ((S)-timolol; 10 μM; 48 h) and expressed relative to 0.5% DMSO-treated control cells.
Redox Biol

Oxidative stress promotes lipid-laden macrophage formation via CYP1B1. [Abstract]

2025 Feb:79:103481. PMID: 39721495
Mater Today Bio

Transdermal delivery of timolol maleate using hydrogel microneedles for the treatment of infantile haemangiomas. [Abstract]

2025 Apr 12:32:101752. PMID: 40290897

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 12:32:101752. [Abstract]

Live-dead cell staining demonstrates the effects of different timolol maleate ((S)-Timolol maleate,TIM; 600-1500 μM; 24 h) concentrations on the cell morphology of 3D-cultured HemECs. Compared to control group, TIM-treated HemECs showed the disappearance of filopodia, exhibited a rounded shape, and had a significant reduction in cell count.

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 12:32:101752. [Abstract]

Cell viability was assessed by CCK-8 in 3D-cultured HemECs after treatment with Timolol maleate ((S)-Timolol maleate,TIM; 600-1500 μM; 24 h) and in 2D-cultured HemECs after treatment with TIM (10-10000 mM; 24 or 48 h). TIM inhibited HemEC growth in a concentration-dependent manner.

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 12:32:101752. [Abstract]

Hemangioma appearance and volume were evaluated in mouse with haemangiomas and tumour grafts after treatment for 2 weeks with Free TIM ((S)-Timolol maleate; 0.5%, 40 μL/cm²; topical administration; three times daily) or BSAMA-TIM-MNs (9 mg/mL; transdermal microneedles; replaced every 3 d). BSAMA-TIM-MNs controlled hemangioma volume more effectively than Free TIM or blank microneedles and produced a decreasing trend in hemangioma size.

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 12:32:101752. [Abstract]

H&E staining of hemangiomas from mouse with haemangiomas and tumour grafts after treatment for 2 weeks with Free TIM ((S)-Timolol maleate; 0.5%, 40 μL/cm²; topical administration; three times daily) or BSAMA-TIM-MNs (9 mg/mL; transdermal microneedles; replaced every 3 d). H & E staining of the haemangioma tissue revealed a reduced number of microvessels in the BSAMA-TIM-MNs group compared to those in the other three groups.

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 12:32:101752. [Abstract]

GLUT-1 immunofluorescence staining and fluorescence intensity in mouse with haemangiomas and tumour grafts after treatment for 2 weeks with Free TIM ((S)-Timolol maleate; 0.5%, 40 μL/cm²; topical administration; three times daily) or BSAMA-TIM-MNs (9 mg/mL; transdermal microneedles; replaced every 3 d). The fluorescence intensity of GLUT-1 was weaker after treatment with BSAMA-TIM-MNs than in the other three groups.

Timolol hemihydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 12:32:101752. [Abstract]

GLUT-1 expression was examined by western blotting in mouse with haemangiomas and tumour grafts after treatment for 2 weeks with Free TIM ((S)-Timolol maleate; 0.5%, 40 μL/cm²; topical administration; three times daily) or BSAMA-TIM-MNs (9 mg/mL; transdermal microneedles; replaced every 3 d). GLUT-1 expression was reduced by treatment with BSAMA-TIM-MNs and Free TIM.
Patent

US20230090708A1.

Protokoll

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr [Content Brief]

[2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Timolol hemihydrate

6 Cited Publications

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Timolol hemihydrate

Publications Citing Use of MedChemExpress (MCE) Timolol hemihydrate

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