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Cat. No.: HY-P992530

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CM355

Name: CM355
Brand: MedChemExpress
SKU: HY-P992530
Availability: PreOrder

(Synonyms: ICP-B02)

CM355 (ICP-B02) is a CD20/CD3 bispecific IgG4 antibody. CM355 exhibits asymmetric affinity binding to CD20 and CD3. CM355 does not bind to Fcγ receptors (FcγR), which is designed to reduce the risk of cytokine release. CM355 can be used for research on B-cell non-Hodgkin lymphoma.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CM355 Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Species Reactivity
- In Vitro
- Target
- Conjugated
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Species Reactivity

Human

In Vitro

Adaptive Immunity

CM355 eliminates malignant B cells by inducing T cell-dependent cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Target

CD3 & CD20

Conjugated

Unconjugated

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[CM355]
Synonyms

ICP-B02
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. SUBCUTANEOUS CM355, A NOVEL BISPECIFIC CD20/CD3 ANTIBODY
SHOWED PROMISING EFFICACY AND FAVORABLE SAFETY PROFILE IN
RELAPSED/REFRACTORY B-CELL NON-HODGKIN LYMPHOMA. EHA Library.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Minimum order quantity

100 mg

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