Arg1 - arginase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29221

Summary

Enables Arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including cellular response to hormone stimulus; gland development; and response to vitamin. Located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study acute necrotizing pancreatitis and hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (Arginase 1). [provided by Alliance of Genome Resources, Apr 2022]

Arg1 Products (1)

mRNA Protein Name
NM_017134.3 NP_058830.2 arginase-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arginase activity IDA
IDA: Inferred from direct assay
4062872 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
1569574 RGD
enables manganese ion binding IDA
IDA: Inferred from direct assay
12820884 RGD
Biological Process GO Annotation Evidence References Source
involved in arginine catabolic process to ornithine IDA
IDA: Inferred from direct assay
15753084 RGD
involved in arginine metabolic process IDA
IDA: Inferred from direct assay
4062872 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
11250887 RGD
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
8460937 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
18001708 RGD
involved in cellular response to interleukin-4 IEP
IEP: Inferred from expression pattern
14618299 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9013624 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
12069499 RGD
involved in collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
20107769 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
7649538 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
8690412 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
18192591 RGD
involved in mammary gland involution IEP
IEP: Inferred from expression pattern
20110414 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
16735458 RGD
involved in positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
11742824 RGD
involved in regulation of L-arginine import across plasma membrane IDA
IDA: Inferred from direct assay
11120661 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
16459053 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
15458774 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
15735325 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
16570515 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
20388547 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9686345 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
15564441 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
18488197 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
19386725 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
14624471 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
18271400 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
14624471 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15888029 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
11686772 RGD
involved in urea cycle IDA
IDA: Inferred from direct assay
4062872 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16872590 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
15753084 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16914676 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arginase-1

  • AI type I arginase

  • arginase, liver

  • liver-type arginase

  • type I arginase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-123823 Nitroaspirin 98.57% Phase 2

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-145331A ARG1-IN-1 hydrochloride Inhibitor 90.0% Unkown
HY-103544 [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 98.48% Unkown
HY-N14001 Naamidine J 99.41% Unkown
HY-169859 EP4 receptor antagonist 7 Antagonist 99.9% Unkown
HY-P1490 Bradykinin (2-9) Modulator 97.15% Unkown
HY-RS00907 ARG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145331 ARG1-IN-1 Inhibitor / Unkown
HY-161061 Arginase inhibitor 7 Inhibitor / Unkown
HY-163426S AFFGHYLYEVAR-(Arg-13C6,15N4) / Unkown
HY-182719 AZD0011 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-N11451 Lacto-N-fucopentaose III Activator 96.54% Unkown
HY-P11405 [D-Arg1,D-Trp5,7,9,Leu11]-Substance P Antagonist / Unkown
HY-P11882 SYN1436 Antagonist / Unkown
HY-P3225 (D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate Antagonist / Unkown
HY-P3880 (D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P Antagonist / Unkown
HY-P3881 (D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P Antagonist / Unkown
HY-P6421S LGPLVEQG-Arg(13C6,15N4) TFA / Unkown
HY-P6422S LAVYQAGA-Arg(13C6,15N4) TFA / Unkown
HY-P6423S CLAVYQAGA-Arg(13C6,15N4) TFA / Unkown
HY-P6424S LGADMEDVCG-Arg(13C6,15N4) TFA / Unkown
HY-RS14543 TINAGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100742AR (R)-GNE-140 (Standard) Inhibitor / Unkown
HY-173452 DT-23 Inhibitor / Unkown
HY-P6425S LCADMEDV-Arg(13C6,15N4) TFA / Unkown
HY-RS17033 Arg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18727 Tinagl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23477 Arg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991870 Anti-Arginase-1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arg1 NCBI NCBI:383
Mus musculus Arg1 NCBI NCBI:11846