YBX1 - Y-box binding protein 1 Gene

Also Known as YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4904

About YBX1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,682,418-42,703,805 (from NCBI)

This gene has 4 transcripts (splice variants), 343 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 220.6), fat (RPKM 121.2) and 25 other tissues.

Summary

This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in MicroRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with Cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

YBX1 Products (2)

mRNA	Protein	Name
NM_004559.5	NP_004550.2	Y-box-binding protein 1
NM_004559.5	NP_004550.2	Y-box-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C5-methylcytidine-containing RNA reader activity	IDA IDA: Inferred from direct assay	31358969	GOA
enables GTPase binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	19561594	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	27559612	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12674497	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	19029303	GOA
involved in CRD-mediated mRNA stabilization	IMP IMP: Inferred from mutant phenotype	19029303	GOA
involved in RNA transport	IMP IMP: Inferred from mutant phenotype	29073095	GOA
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	31358969	GOA
involved in miRNA transport	IDA IDA: Inferred from direct assay	27559612	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	19029303	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	19029303	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18809583	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: Inferred from mutant phenotype	24965446	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18809583	GOA
involved in tRNA transport	IMP IMP: Inferred from mutant phenotype	29073095	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CRD-mediated mRNA stability complex	IDA IDA: Inferred from direct assay	19029303	GOA
part of CRD-mediated mRNA stability complex	IPI IPI: Inferred from physical interaction	19029303	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24965446	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	18335541	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19029303	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	27559612	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YBX1 Protein Structure

CSD

0
100
200
300
324 a.a.

Protein Preferred Names	Protein Names
Y-box-binding protein 1	CCAAT-binding transcription factor I subunit A

YBX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	YBX1	P67809	PITX2	Homo sapiens	Q99697	Anti Bait CoIP	19174163
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Confocal	25497084
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	23986595
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	35271311
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	TAP	22118625
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Bait CoIP	25497084
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	33961781
Intra	YBX1	P67809	LSM3	Homo sapiens	P62310	Anti Tag CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Tag CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	21849455
Intra	YBX1	P67809	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	16797541
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	YBX1	P67809	HNRNPD	Homo sapiens	Q14103-4	Pull Down	12674497
Intra	YBX1	P67809	HNRNPD	Homo sapiens	Q14103-4	Y2H	12674497
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	TAP	24981860
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	Anti Tag CoIP	16797541
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	Pull Down	16797541
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	IF	24965446
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	Anti Bait CoIP	24965446
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	Pull Down	24965446
Cross	YBX1	P67809	CTCF	Gallus gallus	Q08705	Pull Down	15229244

Cross: Cross-species interaction Intra: Intraspecies interaction

YBX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80375	YB1 Antibody (YA004)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
HY-P80936	YB1 Antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Liposarcoma	Lipomatous Cancer
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15916	YBX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16252	Ybx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181098	FKA-9i		/	Unkown
HY-RS23592	Ybx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	YBX1	RGD	RGD:61843
Bos taurus	YBX1	VGNC	VGNC:50233
Mus musculus	YBX1	MGD	MGI:99146
Macaca mulatta	YBX1	VGNC	VGNC:100189
Felis catus	YBX1	VGNC	VGNC:80405
Others	YBX1	NCBI