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SNRNP25 - small nuclear ribonucleoprotein U11/U12 subunit 25 Gene

Also Known as C16orf33

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79622

About SNRNP25

This gene has 7 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in brain (RPKM 19.4), heart (RPKM 18.6) and 25 other tissues.

Summary

Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

SNRNP25 Products (1)

mRNA	Protein	Name
NM_024571.4	NP_078847.2	U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18559850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
U11/U12 small nuclear ribonucleoprotein 25 kDa protein	U11/U12 snRNP 25 kDa protein

SNRNP25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNRNP25	Q9BV90	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	SNRNP25	Q9BV90	TDRKH	Homo sapiens	Q9Y2W6	Validated Y2H	32296183
Intra	SNRNP25	Q9BV90	TDRKH	Homo sapiens	Q9Y2W6	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	TDRKH	Homo sapiens	Q9Y2W6	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	LHX4	Homo sapiens	Q969G2	Y2H Array	25416956
Intra	SNRNP25	Q9BV90	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	25416956
Intra	SNRNP25	Q9BV90	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	SNRNP25	Q9BV90	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	SNRNP25	Q9BV90	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	SNRNP25	Q9BV90	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	25416956
Intra	SNRNP25	Q9BV90	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	SNRNP25	Q9BV90	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SNRNP25	Q9BV90	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	SNRNP25	Q9BV90	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183
Intra	SNRNP25	Q9BV90	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	SNRNP25	Q9BV90	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parosteal Osteosarcoma	Juxtacortical Osteosarcoma Parosteal Osteogenic Sarcoma Osteosarcoma, Juxtacortical
Peripheral Osteosarcoma	Surface Osteosarcoma Bone Surface Osteosarcoma
Li-Fraumeni Syndrome 2	LFS2 Li-Fraumeni Syndrome, Type 2 Li-Fraumeni Syndrome
Li-Fraumeni Syndrome 1	Lfs1
Juxtacortical Chondroma	Periosteal Chondroma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13497	SNRNP25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SNRNP25	VGNC	VGNC:35069
Felis catus	SNRNP25	VGNC	VGNC:65533
Mus musculus	SNRNP25	MGD	MGI:1925622
Canis familiaris	SNRNP25	VGNC	VGNC:46605
Rattus norvegicus	SNRNP25	RGD	RGD:1310922
Others	SNRNP25	NCBI