TDRKH - tudor and KH domain containing Gene

Also Known as TDRD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11022

About TDRKH

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,766,486-151,790,534 (from NCBI)

This gene has 14 transcripts (splice variants), 138 orthologues and 6 paralogues. Broad expression in testis (RPKM 11.8), brain (RPKM 4.0) and 21 other tissues.

Summary

Predicted to enable RNA binding activity. Predicted to be involved in fertilization; gamete generation; and piRNA metabolic process. Predicted to be located in mitochondrion; pi-body; and piP-body. [provided by Alliance of Genome Resources, Apr 2022]

TDRKH Products (4)

mRNA Protein Name
NM_001083963.1 NP_001077432.1 tudor and KH domain-containing protein isoform a
NM_001083964.1 NP_001077433.1 tudor and KH domain-containing protein isoform b
NM_001083965.2 NP_001077434.1 tudor and KH domain-containing protein isoform a
NM_006862.4 NP_006853.2 tudor and KH domain-containing protein isoform a

TDRKH Protein Structure

KH_1

KH_1: KH domain (55 - 115)

KH_1

KH_1: KH domain (127 - 190)

TUDOR

TUDOR: Tudor domain (304 - 422)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 561 a.a.
Protein Preferred Names Protein Names

tudor and KH domain-containing protein

  • putative RNA binding protein

TDRKH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TDRKH Q9Y2W6 ZBTB34 Homo sapiens Q8NCN2
Anti Tag CoIP
33961781
Intra
TDRKH Q9Y2W6 ZFP90 Homo sapiens Q8TF47
Y2H Prey Pooling
32296183
Intra
TDRKH Q9Y2W6 ZFP90 Homo sapiens Q8TF47
Y2H Array
32296183
Intra
TDRKH Q9Y2W6 FAM25C Homo sapiens B3EWG5
Y2H Array
32296183
Intra
TDRKH Q9Y2W6 FAM25C Homo sapiens B3EWG5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Charcot-Marie-Tooth Hereditary Neuropathy

  • Distal Spinal Muscular Atrophy

  • Distal Hereditary Motor Neuropathy

  • Dhmn

  • Hereditary Motor/Sensory Neuropathy

  • Hmsn

  • Dsma

  • Distal Hereditary Motor Neuropathies

  • Spinal Muscular Atrophy Distal

  • Neuropathy, Motor, Distal, Hereditary

  • Charcot-Marie-Tooth Disease
Heinz Body Anemias

  • Heinz Body Anemia

  • Heinz Body Anemias, Alpha-

  • HEIBAN

  • Anemia, Heinz Body

  • Acquired Heinz Body Anemia
Ewing Sarcoma

  • Neuroepithelioma

  • Ewing'S Tumor

  • Primitive Neuroectodermal Tumor

  • Ewings Sarcoma

  • Ewing'S Sarcoma

  • Peripheral Neuroepithelioma

  • ES

  • Ewings Sarcoma-Primitive Neuroectodermal Tumor

  • Localized Peripheral Primitive Neuroectodermal Tumor

  • Peripheral Primitive Neuroectodermal Tumor

  • Ewing Tumor

  • Sarcoma, Ewing'S

  • Ewing Family Of Tumors

  • Extraosseous Ewing Tumor

  • Askin Tumor

  • Ewing'S Family Localized Tumor

  • Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing Sarcoma

  • Localized Ewing'S Sarcoma

  • Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing'S Tumor

  • Pnet Of Thoracopulmonary Region

  • Tumor Of The Ewing Family

  • Skeletal Ewing Sarcoma

  • Osseous Ewing Sarcoma

  • Ppnet

  • Peripheral Pnet

  • Extraskeletal Ewing Sarcoma

  • Eoe

  • Extraosseous Ewing Sarcoma

  • Extraskeletal Ewing Tumor

  • Esft

  • Ewing Sarcoma Family Of Tumors

  • Pne

  • Pnet

  • Pnet Of The Chest Wall

  • Sarcoma, Ewing

  • Neuroectodermal Tumors, Primitive, Peripheral

  • Neuroectodermal Tumor, Primitive

  • Disorder Of Eye

  • Askin'S Tumor

  • Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

  • Neuroepithelioma, Peripheral
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14340 TDRKH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TDRKH RGD RGD:1311196
Canis familiaris TDRKH VGNC VGNC:47227
Felis catus TDRKH VGNC VGNC:66052
Mus musculus TDRKH MGD MGI:1919884
Macaca mulatta TDRKH VGNC VGNC:78300
Bos taurus TDRKH VGNC VGNC:55688
Others TDRKH NCBI