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Cat. No.: HY-139865

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142I5

142I5 is a potent ML-IAP Lys-covalent inhibitor with an IC₅₀ value of 11 nM.

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CAS No.: 2865171-75-9
Formule: C₂₉H₃₆FN₅O₇S
Masse moléculaire:617.69

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

142I5 Chemical Structure

CAS No.: 2865171-75-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

142I5 is a potent ML-IAP Lys-covalent inhibitor with an IC₅₀ value of 11 nM.

Chemical Information

CAS No. 2865171-75-9
Masse moléculaire 617.69
Formule C₂₉H₃₆FN₅O₇S
SMILES

O=S(C1=CC=C(OC)C(C(NC[C@H](NC([C@@H](NC)C)=O)C(N2[C@H](C(N[C@@H]3CCC4=C3C=CC=C4)=O)CCC2)=O)=O)=C1)(F)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Udompholkul P, et al. Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein. J Med Chem. 2021 Nov 11;64(21):16147-16158. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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