RO-7
RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.
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- CAS No.: 1370241-45-4
- Formule: C24H20F3N3O3S
- Masse moléculaire:487.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
11.9 μM
Compound: 76; RO-7
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Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
|
[PMID: 28118010] |
| MDCK | CC50 |
86.2 μM
Compound: 76; RO-7
|
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
|
[PMID: 28118010] |
RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1370241-45-4
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Masse moléculaire 487.49
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Formule C24H20F3N3O3S
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SMILES
O=C1N([C@H](C)C(F)(F)F)CN([C@@H]2C3=CC=CC=C3SCC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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