Anticancer agent 53
Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity.
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- CAS No.: 1926985-18-3
- Formule: C31H25FN4O6S
- Masse moléculaire:600.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
4.3 nM
Compound: c20
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Cytotoxicity against human A549 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 31881457] |
| Hep 3B2 | IC50 |
2.3 nM
Compound: c20
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Cytotoxicity against human Hep3B cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 31881457] |
| KB | IC50 |
24 nM
Compound: c20
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Cytotoxicity against human KB cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human KB cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 31881457] |
| MCF7 | IC50 |
42 nM
Compound: c20
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Cytotoxicity against human MCF7 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 31881457] |
| MDA-MB-231 | IC50 |
96.3 nM
Compound: c20
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Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 31881457] |
Anticancer agent 53 (compound c20) (0-1000 nM; 72 h) shows cytotoxicity with IC50s of 2.3, 42.0, 4.3, 96.3, 24.0, 47.4 nM for Hep3B, MCF7, A549, MDA-MB-231, KB, KB-vin cells, respectively[1].
Anticancer agent 53 (0.025, 0.05, 0.1 µM; 48 h) induces apoptosis and cell cycle arrest in S/G2/M phases[1].
Anticancer agent 53 (0.1. 0.2 µM; 6 h) inhibits topoisomerase I activity in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:0.025, 0.05, 0.1 µM
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Incubation Time:0-48 h
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Result:Induced cell cycle arrest in S/G2/M phases.
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Cell Line:A549 cells
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Concentration:0.025, 0.05, 0.1 µM
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Incubation Time:0-48 h
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Result:Induced apoptosis with the proapoptotic protein Caspase-3 and Bax were up-regulated and anti-apoptotic Bcl-2 was down-regulated.
Anticancer agent 53 (2 mg/kg; i.v; every other day for two weeks) shows antitumor effect in HCC mouse model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/C mice[1]
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Dosage:5, 25 and 50 mg/kg (saline with 5% DMSO and 5% Cremophor EL)
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Administration:I.p.
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Result:Showed no body weight loss, no significant liver damage, no significant damage occurred in spleens and livers.
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Animal Model:6-8 weeks Female BALB/c nude mice (Hep3B cells)[1]
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Dosage:1, 2 mg/kg
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Administration:I.v., every other day for total 7 doses
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Result:Significantly inhibited tumor growth with an average body weight of 24 g and an average tumor volume of 3800 mm[3] at 1 mg/kg and an average body weight of 22 g and average tumor volume 2380 mm[3] at 2 mg/kg.
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Animal Model:6-8 weeks FVB/N mice (HCC mouse model)[1]
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Dosage:2 mg/kg
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Administration:I.v.; every other day for two weeks
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Result:Inhibited the tumor growth and reduced the liver weights, and t inhibited proliferation of HCC tissues.
Chemical Information
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CAS No. 1926985-18-3
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Masse moléculaire 600.62
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Formule C31H25FN4O6S
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SMILES
CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC=CC=C5C=C4CN3C2=O)=O)OC([C@@H](NC(NC(C6=CC=C(C=C6)F)=O)=S)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 53 Related Classifications
HY-146407 Related Classifications
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