Antitumor agent-174
Antitumor agent-174 (Compound 10) directly engages the N-terminal site of Hsp90 and promotes the degradation of β-catenin, thereby suppressing the Wnt/β-catenin signaling. Antitumor agent-174 effectively inhibits proliferation, induce S and G2/M phases arrest and block the clonogenic ability in CRC cells. Antitumor agent-174 down-regulates CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, and upregulaties P21 proteins. Antitumor agent-174 has significant anti-tumor efficacy against colorectal cancer (CRC) with excellent pharmacokinetics and low toxicity.
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- Formule: C20H18Cl2N2
- Masse moléculaire:357.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK1/cyclinB1 |
HSP90 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
8.31 μM
Compound: 10
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Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay
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[PMID: 39018921] |
| RKO | IC50 |
7.97 μM
Compound: 10
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Antiproliferative activity against human RKO cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human RKO cells incubated for 24 hrs by MTT assay
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[PMID: 39018921] |
Chemical Information
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Masse moléculaire 357.28
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Formule C20H18Cl2N2
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SMILES
CC12C3=C(C(C=C(Cl)C=C4)=C4N3)CCN1CCC5=C2C=CC(Cl)=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-174 Related Classifications
HY-161826 Related Classifications
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