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Cat. No.: HY-106650

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CMDA

CMDA is a prodrug that can release cytotoxic molecules under the action of CPG2. CMDA can be used for cancer research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 122665-73-0
Formule: C₁₇H₂₃ClN₂O₈S
Masse moléculaire:450.89

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CMDA Chemical Structure

CAS No.: 122665-73-0

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

CMDA is a prodrug that can release cytotoxic molecules under the action of CPG2. CMDA can be used for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
LoVo	IC₅₀	>500 μM Compound: 1	Inhibitory concentration was evaluated against colorectal tumar cell line LoVo Inhibitory concentration was evaluated against colorectal tumar cell line LoVo	[PMID: 8676345]
LS174T	IC₅₀	>800200 μM Compound: 40	Compound was evaluated for its cytotoxicity without carboxypeptidase G2 in the colorectal cell line LS174T for 1 hour Compound was evaluated for its cytotoxicity without carboxypeptidase G2 in the colorectal cell line LS174T for 1 hour	[PMID: 8057284]
LS174T	IC₅₀	200 μM Compound: 40	Compound was evaluated for its cytotoxicity with carboxypeptidase G2 in the colorectal cell line LS174T for 1 hour Compound was evaluated for its cytotoxicity with carboxypeptidase G2 in the colorectal cell line LS174T for 1 hour	[PMID: 8057284]
WiDr	IC₅₀	100 μM Compound: CMDA	Compound was tested for cytotoxicity in WiDr cells engineered for stable expression of surface-tethered CPG2 Compound was tested for cytotoxicity in WiDr cells engineered for stable expression of surface-tethered CPG2	[PMID: 12699387]
WiDr	IC₅₀	3230 μM Compound: CMDA	Compound was tested for cytotoxicity in WiDr cells engineered for stable expression of beta-galactosidase Compound was tested for cytotoxicity in WiDr cells engineered for stable expression of beta-galactosidase	[PMID: 12699387]

Chemical Information

CAS No. 122665-73-0
Masse moléculaire 450.89
Formule C₁₇H₂₃ClN₂O₈S
SMILES

CS(OCCN(C1=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C1)CCCl)(=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yu T, et al. Development of ZD2767P-carboxypeptidase G2-ultrasound therapy against cisplatin-resistant cancer. Front Oncol. 2023 May 18;13:1151613. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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