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Cat. No.: HY-184176

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DBCO-PEG3-AP1867

DBCO-PEG3-AP1867 is a bifunctional molecular building block that binds to FKBP12^F36V, and also a SPAAC-compatible reagent suitable for synthesizing O-GlcNAcylation-targeting chimeras (OGTACs) against c-Myc. DBCO-PEG3-AP1867 is applicable to cancer-related research.

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Formule: C₆₅H₇₈N₄O₁₅
Masse moléculaire:1155.33

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DBCO-PEG3-AP1867 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

DBCO-PEG3-AP1867 successfully undergoes SPAAC reaction with azide-modified c-Myc-binding oligonucleotides to form a bifunctional OGTAC construct targeting c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) potently induces O-GlcNAcylation of c-Myc and the proximity interaction between c-Myc and OGT in HEK293T-fOGT cells overexpressing Flag-c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (0.1-5 μg/mL; 24 h) significantly reduces the viability of HeLa-fOGT cells^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) remodels the genomic occupancy of c-Myc and significantly downregulates MALAT1 expression in a c-Myc O-GlcNAcylation-dependent manner in HeLa-fOGT cells and HEK293T-fOGT cells overexpressing c-Myc^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1155.33
Formule C₆₅H₇₈N₄O₁₅
SMILES

COC(C=C1)=C(OC)C=C1CC[C@@H](OC([C@H]2N(C([C@@H](CC)C3=CC(OC)=C(OC)C(OC)=C3)=O)CCCC2)=O)C4=CC(OCC(NCCOCCOCCOCCNC(CCC(N5C(C=CC=C6)=C6C#CC(C=CC=C7)=C7C5)=O)=O)=O)=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Xu T, et al. Rewiring c-Myc Transcriptional Activity with an O-GlcNAcylation Targeting Chimera (OGTAC). bioRxiv. 2026.

Calculators

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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