CKAP4 - cytoskeleton associated protein 4 Gene

Also Known as p63; CLIMP63; CLIMP-63; ERGIC-63

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10970

About CKAP4

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,237,881-106,248,020 (from NCBI)

This gene has 3 transcripts (splice variants), 192 orthologues and 7 paralogues. Ubiquitous expression in bone marrow (RPKM 41.9), placenta (RPKM 30.9) and 25 other tissues.

Summary

Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

CKAP4 Products (1)

mRNA	Protein	Name
NM_006825.4	NP_006816.2	cytoskeleton-associated protein 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19401338	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	14741744	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	24454821	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytoskeleton-associated protein 4	63 kDa membrane protein

Recombinant CKAP4 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P700976	CKAP4 Protein, Human (His)	Q07065 (H128-V602)	≥ 90%, as determined by reducing SDS-PAGE.

CKAP4 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P810724	CKAP4 Antibody (YA9968)	WB, ICC/IF, FC	Human
HY-P84944	CKAP4 Antibody	WB	Human, Mouse

Related Diseases

Diseases	Alias
Cystitis	Infective Cystitis Urocystitis Pyocystitis
Bladder Exstrophy	Exstrophy Of The Bladder Classic Exstrophy Of The Bladder
Axenfeld-Rieger Syndrome, Type 1	Axenfeld-Rieger Syndrome Type 1 RIEG1 Rieg Rgs Rieger Syndrome Type 1 Rieger Syndrome, Type 1 Axenfeld-Rieger Syndrome 1 Iridogoniodysgenesis With Somatic Anomalies
Retinitis Pigmentosa 20	RP20 Retinitis Pigmentosa, Type 20
Spastic Paraplegia 36, Autosomal Dominant	SPG36 Hereditary Spastic Paraplegia 36 Autosomal Dominant Spastic Paraplegia Type 36 Autosomal Dominant Spastic Paraplegia 36
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-178193A	(Rac)-Chem-0199	Inhibitor	99.81%	Unkown
HY-178193	Chem-0199	Inhibitor	/	Unkown
HY-RS02734	CKAP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19421	Ckap4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25912	Ckap4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CKAP4	VGNC	VGNC:39288
Felis catus	CKAP4	VGNC	VGNC:83533
Mus musculus	CKAP4	MGD	MGI:2444926
Bos taurus	CKAP4	VGNC	VGNC:27382
Rattus norvegicus	CKAP4	RGD	RGD:1311989
Macaca mulatta	CKAP4	VGNC	VGNC:71190
Others	CKAP4	NCBI