DNASE1L2 - deoxyribonuclease 1 like 2 Gene

Also Known as DNAS1L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1775

About DNASE1L2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,236,444-2,238,711 (from NCBI)

This gene has 6 transcripts (splice variants), 218 orthologues and 3 paralogues. Broad expression in skin (RPKM 3.2), brain (RPKM 0.6) and 14 other tissues.

Summary

Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process, endonucleolytic. Predicted to act upstream of or within corneocyte development and hair follicle development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DNASE1L2 Products (2)

mRNA Protein Name
NM_001301680.2 NP_001288609.1 deoxyribonuclease-1-like 2 precursor
NM_001374.3 NP_001365.1 deoxyribonuclease-1-like 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNASE1L2 Protein Structure

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (46 - 288)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

deoxyribonuclease-1-like 2

  • DNase I homolog protein DHP1

DNASE1L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
DNASE1L2 Q92874 HSPA5 Homo sapiens P11021
Anti Tag CoIP
33961781
Intra
DNASE1L2 Q92874 HSPA5 Homo sapiens P11021
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chronic Follicular Conjunctivitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03896 DNASE1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DNASE1L2 VGNC VGNC:28134
Rattus norvegicus DNASE1L2 RGD RGD:1583566
Macaca mulatta DNASE1L2 VGNC VGNC:71948
Felis catus DNASE1L2 VGNC VGNC:61553
Mus musculus DNASE1L2 MGD MGI:1913955
Others DNASE1L2 NCBI