H77-77
H77-77 is a selective MAO-A inhibitor with blood-brain barrier permeability, exhibiting an IC50 of 7.4 μM against rat MAO-A. H77-77 accumulates via uptake by serotonergic and noradrenergic neurons. H77-77 releases norepinephrine and serotonin from intracellular neuronal storage sites. H77-77 can be used in studies related to neurological disorders.
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- CAS No.: 21618-99-5
- Formule: C10H15NO
- Masse moléculaire:165.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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rMAO-A 7.4 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 160-200 g)[1]
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Dosage:1.25 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
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Administration:s.c.
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Result:Produced 35% inhibition of MAO inside serotonergic neurons in the hypothalamus, with minimal inhibition outside these neurons at 1.25 mg/kg s.c.
Produced 78% inhibition of MAO inside serotonergic neurons and 15% inhibition outside these neurons, and 60% inhibition inside noradrenergic neurons and 11% inhibition outside these neurons at 10 mg/kg s.c.
Reduced MAO inhibition inside serotonergic neurons to 27% at the 10 mg/kg s.c. dose when pretreated with norzimeldine.
Reduced MAO inhibition inside noradrenergic neurons to 20% at the 10 mg/kg s.c. dose when pretreated with CPP199.
Showed no selective inhibition of MAO inside dopaminergic neurons in the striatum.
Chemical Information
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CAS No. 21618-99-5
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Masse moléculaire 165.24
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Formule C10H15NO
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SMILES
OC1=CC(=CC=C1C)CC(N)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Fagervall I, et al. Selective inhibition by 4,alpha-dimethyl-m-tyramine (H77/77) and 4-methyl-alpha-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. 1988 Aug;338(2):143-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H77-77 Related Classifications
HY-124331 Related Classifications
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