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Cat. No.: HY-122151

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MPT0B002

MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase.

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CAS No.: 946077-08-3
Formule: C₁₉H₁₉NO₄
Masse moléculaire:325.36

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MPT0B002 Chemical Structure

CAS No.: 946077-08-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.12 μM Compound: 4d	Cytotoxicity against human A549 cells after 72 hrs by XTT assay Cytotoxicity against human A549 cells after 72 hrs by XTT assay	[PMID: 19647439]
A549	IC₅₀	0.12 μM Compound: 7	Cytotoxicity against human A549 cells after 72 hrs by XTT method Cytotoxicity against human A549 cells after 72 hrs by XTT method	[PMID: 18502133]
A549	IC₅₀	0.12 μM Compound: XIII	Cytotoxicity against human A549 cells after 72 hrs by XTT assay Cytotoxicity against human A549 cells after 72 hrs by XTT assay	[PMID: 19939521]
A549	IC₅₀	190 nM Compound: 4	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by XTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by XTT assay	[PMID: 23470139]
Bel-7402	IC₅₀	21 nM Compound: 8b	Antiproliferative activity against human Bel7402 cells Antiproliferative activity against human Bel7402 cells	[PMID: 17482458]
CCRF-CEM	IC₅₀	18 nM Compound: 8b	Antiproliferative activity against human CEM cells Antiproliferative activity against human CEM cells	[PMID: 17482458]
DU-145	IC₅₀	26 nM Compound: 8b	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 17482458]
HeLa	IC₅₀	0.034 μM Compound: 7	Cytotoxicity against human HeLa cells after 72 hrs by XTT method Cytotoxicity against human HeLa cells after 72 hrs by XTT method	[PMID: 18502133]
HeLa	IC₅₀	0.034 μM Compound: XIII	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	[PMID: 19939521]
HeLa	IC₅₀	0.035 μM Compound: 4d	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	[PMID: 19647439]
HeLa	IC₅₀	25 nM Compound: 4	Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by XTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by XTT assay	[PMID: 23470139]
HL-60	IC₅₀	27 nM Compound: 4	Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by XTT assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by XTT assay	[PMID: 23470139]
HT-29	IC₅₀	10.5 nM Compound: 14	Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]
HT-29	IC₅₀	27 nM Compound: 4	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by XTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by XTT assay	[PMID: 23470139]
KB	IC₅₀	13.6 nM Compound: 14	Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]
MCF7	IC₅₀	9.2 nM Compound: 8b	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 17482458]
MKN-45	IC₅₀	11.2 nM Compound: 14	Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]
MOLT-3	IC₅₀	18 nM Compound: 8b	Antiproliferative activity against human Molt3 cells Antiproliferative activity against human Molt3 cells	[PMID: 17482458]
NCI-H460	IC₅₀	14.1 nM Compound: 14	Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]
PC-3	IC₅₀	25 nM Compound: 8b	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 17482458]
TSGH	IC₅₀	13.4 nM Compound: 14	Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]

In Vitro

MPT0B002 (1-1000 nM; 48 h) induces G2/M-phase cell cycle arrest^[1].
MPT0B002 (100 nM; 24 h) inhibits cell viability in a dose-dependent manner in K562, BaF3/p210, and BaF3/T315I cells^[1].
MPT0B002 (100 nM; 48 h) induces apoptosis and can downregulate both Bcr-Abl and Bcr-Abl-T315I mRNA expressions and protein levels and the downstream signaling pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

K562, BaF3/p210, and BaF3/T315I cells
Concentration:

1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time:

48 h
Result:

Inhibited cell viability in a dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

K562, BaF3/p210, and BaF3/T315I cells
Concentration:

100 nM
Incubation Time:

24 h
Result:

Induced G2/M-phase cell cycle arrest.

Apoptosis Analysis^[1]

Cell Line:

K562, BaF3/p210, and BaF3/T315I cells
Concentration:

100 nM
Incubation Time:

48 h
Result:

Induced apoptosis and caspase-3 pathway.

Western Blot Analysis^[1]

Cell Line:

K562, BaF3/p210, and BaF3/T315I cells
Concentration:

100 nM
Incubation Time:

48 h
Result:

Significantly reduced the expression level of Bcr-Abl, and reduced the phosphorylations of Crkl and Stat5.

Chemical Information

CAS No. 946077-08-3
Masse moléculaire 325.36
Formule C₁₉H₁₉NO₄
SMILES

O=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=CC3=C(C=C2)N(C=C3)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yi-Yen Yeh, et al. MPT0B002, a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells. Invest New Drugs. 2017 Aug;35(4):427-435. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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