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Cat. No.: HY-130303

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Nutlin-2

Nutlin-2 is an inhibitor of the interaction between p53 and MDM2, with an IC₅₀ of 0.14 μM. Nutlin-2 disrupts the p53-MDM2 protein-protein interaction by occupying the hydrophobic pocket on MDM2 that normally binds to the hydrophobic residues of p53.

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CAS No.: 548472-76-0
Formule: C₃₁H₃₄Br₂N₄O₄
Masse moléculaire:686.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nutlin-2 Chemical Structure

CAS No.: 548472-76-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

Nutlin-2 inhibits the p53-MDM2 protein-protein interaction in a cell-free assay with an IC₅₀ of 0.14 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 548472-76-0
Masse moléculaire 686.43
Formule C₃₁H₃₄Br₂N₄O₄
SMILES

O=C(N1[C@@H](C2=CC=C(Br)C=C2)[C@@H](C3=CC=C(Br)C=C3)N=C1C4=CC=C(OC)C=C4OCC)N5CCN(CCO)CC5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Miyazaki M, et al. Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships. Bioorg Med Chem Lett. 2012;22(20):6338-6342. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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