548472-76-0
Chemical Structure
Nutlin-2
- CAS No.: 548472-76-0
- Formula:C31H34Br2N4O4
- Molecular Weight:686.43
IUPAC Name: ((4R,5S)-4,5-bis(4-bromophenyl)-2-(2-ethoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazol-1-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone
InChIKey: PVRYEWOXWGDQHA-WDYNHAJCSA-N
SMILES: O=C(N1[C@@H](C2=CC=C(Br)C=C2)[C@@H](C3=CC=C(Br)C=C3)N=C1C4=CC=C(OC)C=C4OCC)N5CCN(CCO)CC5
Biological Activity: Nutlin-2 is an inhibitor of the interaction between p53 and MDM2, with an IC50 of 0.14 μM. Nutlin-2 disrupts the p53-MDM2 protein-protein interaction by occupying the hydrophobic pocket on MDM2 that normally binds to the hydrophobic residues of p53[1].
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Nutlin-2 | Nutlin-2 is an inhibitor of the interaction between p53 and MDM2, with an IC50 of 0.14 μM. Nutlin-2 disrupts the p53-MDM2 protein-protein interaction by occupying the hydrophobic pocket on MDM2 that normally binds to the hydrophobic residues of p53. | |||||||||||||||||||||
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Keywords
