2. Apoptosis
  3. MDM-2/p53
  4. Nutlin-2

Nutlin-2 is an inhibitor of the interaction between p53 and MDM2, with an IC50 of 0.14 μM. Nutlin-2 disrupts the p53-MDM2 protein-protein interaction by occupying the hydrophobic pocket on MDM2 that normally binds to the hydrophobic residues of p53.

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Nutlin-2

Nutlin-2 Chemical Structure

CAS No. : 548472-76-0

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Nutlin-2 Related Antibodies

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Description

Nutlin-2 is an inhibitor of the interaction between p53 and MDM2, with an IC50 of 0.14 μM. Nutlin-2 disrupts the p53-MDM2 protein-protein interaction by occupying the hydrophobic pocket on MDM2 that normally binds to the hydrophobic residues of p53[1].

In Vitro

Nutlin-2 inhibits the p53-MDM2 protein-protein interaction in a cell-free assay with an IC50 of 0.14 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nutlin-2 Related Antibodies
Molecular Weight

686.43

Formula

C31H34Br2N4O4
CAS No.
SMILES

O=C(N1[C@@H](C2=CC=C(Br)C=C2)[C@@H](C3=CC=C(Br)C=C3)N=C1C4=CC=C(OC)C=C4OCC)N5CCN(CCO)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nutlin-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nutlin-2548472-76-0Nutlin2Nutlin 2MDM-2/p53p53-MDM2 protein-protein interactionp53MDM2Inhibitorinhibitorinhibit

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