PF-7006
PF-7006 is an Mps1 kinase inhibitor with a Ki value of 0.27 nM and an IC50 value of 2.5 nM. PF-7006 interferes with cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reducing histone H3 levels, and shortening the duration of mitosis, leading to apoptosis in cancer cells. Combined use of PF-7006 with Palbociclib (HY-50767) increases cancer cell tolerance to PF-7006. PF-7006 can be used for breast cancer research.
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- CAS No.: 2771955-09-8
- Formule: C22H26N8O2
- Masse moléculaire:434.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50：2.5 nM (Mps1) [1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
2 nM
Compound: 38; PF-7006
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Antiproliferative activity against human MDA-MB-231 cells after 7 days by cell titer-glo assay
Antiproliferative activity against human MDA-MB-231 cells after 7 days by cell titer-glo assay
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[PMID: 31121430] |
Chemical Information
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CAS No. 2771955-09-8
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Masse moléculaire 434.49
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Formule C22H26N8O2
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SMILES
N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC5CCOCC5)=C12
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-7006 Related Classifications
HY-164519 Related Classifications
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