Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent pseudorabies virus (PRV) inhibitor (EC50: 0.29 nM). Pseudorabies virus-IN-1 inhibits PRV replication by targeting PRV deoxyribonucleic acid polymerase (DNA pol). Pseudorabies virus-IN-1 can effectively inhibit PRV replication at low concentrations (MIC80: 1.6-8 nM). Pseudorabies virus-IN-1 can be used to study PRV infection.
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- Formule: C27H23ClF2N4O2
- Masse moléculaire:508.95
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Pseudorabies virus-IN-1 (Compound C2) (0.1-1000 nM, 48 h) can inhibit 50% of PRV replication in PK15 cells infected with PRV (MOI=1) at very low concentrations (EC50: 0.29 nM), shows significant activity[1].
Pseudorabies virus-IN-1 (0.05-100 nM, 72 h) has relatively low cytotoxicity in PK15 cells (CC50: 28 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | Plasma Concentration | AUC | T1/2 | Tmax | MRT |
|---|---|---|---|---|---|---|---|
| Mice[1] | 30 mg/kg | i.p. | 342.5 ng/mL | 1022 ng·h/mL | 3.24 h | 1.5 h | 3.15 h |
In Vivo
Pseudorabies virus-IN-1 (30 mg/kg, i.p. three times daily for 7 consecutive days) makes all mice in the treatment group survive, while the mortality rate of the control group reached 80%, and the number of viral copies in the treatment group was significantly lower than that in the control group (about 3 times less).[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (female, aged 6-8 weeks) injected with PRV (5 x 107 copies) in 100 µL of PBS[1]
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Dosage:30 mg/kg
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Administration:i.p. three times daily for 7 consecutive days
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Result:The virus load in brain tissue and plasma was significantly reduced, and no mice died.
Chemical Information
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Masse moléculaire 508.95
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Formule C27H23ClF2N4O2
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SMILES
O=C1C(C(NCC2=CC(Cl)=CC=C2F)=O)=CN(C3=CC=CC=C3)C4=C1C=C(F)C(N5CCNCC5)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pseudorabies virus-IN-1 Related Classifications
HY-173216 Related Classifications
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