BCN

Bis-PEG23-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-PEG23-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

bis-PEG2-endo-BCN is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). bis-PEG2-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

endo-BCN-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

endo-BCN-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. endo-BCN-PEG2-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

BCN-HS-PEG2-bis(PNP) is a p-nitrophenyl ADC linker that can be used for further coupling of ADC toxins with peptide linkers. BCN-HS-PEG2-bis(PNP) can be combined with vc-PABC-MMAE (HY-15162) to form drug-linker conjugates for ADCs.

5-JOE BCN is a derivative of JOE featuring a BCN (bicyclo[6.1.0]nonyne) group, designed for copper-free click chemistry reactions. 5-JOE BCN can be used for copper-free click chemistry-based bioconjugation (Ex/Em = 520/548 nm) .

MEAP (2-(4-Morpholinoanilino-6-[(2-exo-norbornyl) amino)-purine) is a NEDD9-STAT3 modulator. MEAP disrupts NEDD9-STAT3 interaction, driving STAT3 Y705 dephosphorylation. MEAP induces G₂/M phase arrest. MEAP can be used for the research of anaplastic thyroid cancer.

SiR-BCN is a Fluorophore-labeled bicyclononyne. SiR-BCN can be used for protein modification and labeling studies.

BCN-HS-PEG2-VA-PABC is a ADC linker that can be used in the synthesis of PL1601 (HY-47018).

DFO-BCN is a drug intermediate, that can be used for synthesis of PET/CT imaging agent DFO-CPC634 through click chemistry.

Coumarin-PEG2-endoBCN is a fluorescent dye containing a coumarin fluorophore and can be used as a click chemistry reagent.

exo-BCN-Fmoc-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-Fmoc-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

(Rac)-BCN-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. (Rac)-BCN-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Cy3-PEG7-exo-BCN is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-exo-BCN contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.

Cy3-PEG3-exo-BCN is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-exo-BCN contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.

Cy3-PEG3-endo-BCN is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-endo-BCN contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.

Cy3-PEG2-exo-BCN is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-exo-BCN contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.

BCN-exo-PEG2-maleimide is an ADC Linker containing 2 PEG units. BCN-exo-PEG2-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

Cy5-PEG7-endo-BCN is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-endo-BCN contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.

Bis-PEG12-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-PEG12-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.