2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-798

CRBN ligand-798 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-798 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-798

CRBN ligand-798 Chemical Structure

CAS No. : 1448189-90-9

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10 mM * 1 mL in DMSO
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CRBN ligand-798 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-798 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-798 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-798 Related Antibodies
Molecular Weight

353.87

Formula

C16H20ClN3O2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC1=C(C2=CC=C(CNC(=O)[C@H]3NC[C@H](O)C3)C=C2)SC=N1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (70.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8259 mL 14.1295 mL 28.2590 mL
5 mM 0.5652 mL 2.8259 mL 5.6518 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 96.93%

SDS (393 KB)

COA (247 KB) HNMR (186 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8259 mL 14.1295 mL 28.2590 mL 70.6474 mL
5 mM 0.5652 mL 2.8259 mL 5.6518 mL 14.1295 mL
10 mM 0.2826 mL 1.4129 mL 2.8259 mL 7.0647 mL
15 mM 0.1884 mL 0.9420 mL 1.8839 mL 4.7098 mL
20 mM 0.1413 mL 0.7065 mL 1.4129 mL 3.5324 mL
25 mM 0.1130 mL 0.5652 mL 1.1304 mL 2.8259 mL
30 mM 0.0942 mL 0.4710 mL 0.9420 mL 2.3549 mL
40 mM 0.0706 mL 0.3532 mL 0.7065 mL 1.7662 mL
50 mM 0.0565 mL 0.2826 mL 0.5652 mL 1.4129 mL
60 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1775 mL
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CRBN ligand-798 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-7981448189-90-9CRBN ligand798CRBN ligand 798Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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