CRBN ligand-798
Based on 1 Customer Validation
CRBN ligand-798 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-798 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 96.93%
- CAS No.: 1448189-90-9
- Formula: C16H20ClN3O2S
- Molecular Weight:353.87
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1448189-90-9
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Appearance Solid
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Molecular Weight 353.87
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Formula C16H20ClN3O2S
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Color White to light yellow
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SMILES
CC1=C(C2=CC=C(CNC(=O)[C@H]3NC[C@H](O)C3)C=C2)SC=N1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 25 mg/mL (70.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (242 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8259 mL | 14.1295 mL | 28.2590 mL | 70.6474 mL |
| 5 mM | 0.5652 mL | 2.8259 mL | 5.6518 mL | 14.1295 mL | |
| 10 mM | 0.2826 mL | 1.4129 mL | 2.8259 mL | 7.0647 mL | |
| 15 mM | 0.1884 mL | 0.9420 mL | 1.8839 mL | 4.7098 mL | |
| 20 mM | 0.1413 mL | 0.7065 mL | 1.4129 mL | 3.5324 mL | |
| 25 mM | 0.1130 mL | 0.5652 mL | 1.1304 mL | 2.8259 mL | |
| 30 mM | 0.0942 mL | 0.4710 mL | 0.9420 mL | 2.3549 mL | |
| 40 mM | 0.0706 mL | 0.3532 mL | 0.7065 mL | 1.7662 mL | |
| 50 mM | 0.0565 mL | 0.2826 mL | 0.5652 mL | 1.4129 mL | |
| 60 mM | 0.0471 mL | 0.2355 mL | 0.4710 mL | 1.1775 mL |
CRBN ligand-798 Related Classifications
HY-43983 Related Classifications
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