2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-886

CRBN ligand-886 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-886 can be linked to a target protein ligand via a linker to form a PROTAC.

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CRBN ligand-886

CRBN ligand-886 Chemical Structure

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CRBN ligand-886 Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase:

Voir toutes les isoformes
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-886 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-886 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-886 Related Antibodies
Masse moléculaire

213.23

Formule

C₁₃H₁₁NO₂
SMILES

C#CC1C=C(C=CC=1)C2C(=O)NC(=O)CC2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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CRBN ligand-886 Related Classifications

  • Calculateur de molarité

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-886CRBN ligand886CRBN ligand 886Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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CRBN ligand-886
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HY-W999575
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