CRBN ligand-888
Based on 1 Customer Validation
CRBN ligand-888 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-888 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.36%
- CAS No.: 53727-25-6
- Formula: C10H7BrN2O2
- Molecular Weight:267.08
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
-
Help & FAQs
Biological Activity
|
Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 53727-25-6
-
Appearance Solid
-
Molecular Weight 267.08
-
Formula C10H7BrN2O2
-
Color White to light brown
-
SMILES
O=C1C=CN(C(=O)N1)C2=CC=C(Br)C=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (187.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (244 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7442 mL | 18.7210 mL | 37.4420 mL | 93.6049 mL |
| 5 mM | 0.7488 mL | 3.7442 mL | 7.4884 mL | 18.7210 mL | |
| 10 mM | 0.3744 mL | 1.8721 mL | 3.7442 mL | 9.3605 mL | |
| 15 mM | 0.2496 mL | 1.2481 mL | 2.4961 mL | 6.2403 mL | |
| 20 mM | 0.1872 mL | 0.9360 mL | 1.8721 mL | 4.6802 mL | |
| 25 mM | 0.1498 mL | 0.7488 mL | 1.4977 mL | 3.7442 mL | |
| 30 mM | 0.1248 mL | 0.6240 mL | 1.2481 mL | 3.1202 mL | |
| 40 mM | 0.0936 mL | 0.4680 mL | 0.9360 mL | 2.3401 mL | |
| 50 mM | 0.0749 mL | 0.3744 mL | 0.7488 mL | 1.8721 mL | |
| 60 mM | 0.0624 mL | 0.3120 mL | 0.6240 mL | 1.5601 mL | |
| 80 mM | 0.0468 mL | 0.2340 mL | 0.4680 mL | 1.1701 mL | |
| 100 mM | 0.0374 mL | 0.1872 mL | 0.3744 mL | 0.9360 mL |
CRBN ligand-888 Related Classifications
HY-W999559 Related Classifications
Powered by Bioz