2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-888

CRBN ligand-888 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-888 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-888

CRBN ligand-888 Chemical Structure

CAS No. : 53727-25-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
25 mg In-stock
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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CRBN ligand-888 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-888 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-888 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-888 Related Antibodies
Molecular Weight

267.08

Formula

C10H7BrN2O2
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C1C=CN(C(=O)N1)C2=CC=C(Br)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (187.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7442 mL 18.7210 mL 37.4420 mL
5 mM 0.7488 mL 3.7442 mL 7.4884 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7442 mL 18.7210 mL 37.4420 mL 93.6049 mL
5 mM 0.7488 mL 3.7442 mL 7.4884 mL 18.7210 mL
10 mM 0.3744 mL 1.8721 mL 3.7442 mL 9.3605 mL
15 mM 0.2496 mL 1.2481 mL 2.4961 mL 6.2403 mL
20 mM 0.1872 mL 0.9360 mL 1.8721 mL 4.6802 mL
25 mM 0.1498 mL 0.7488 mL 1.4977 mL 3.7442 mL
30 mM 0.1248 mL 0.6240 mL 1.2481 mL 3.1202 mL
40 mM 0.0936 mL 0.4680 mL 0.9360 mL 2.3401 mL
50 mM 0.0749 mL 0.3744 mL 0.7488 mL 1.8721 mL
60 mM 0.0624 mL 0.3120 mL 0.6240 mL 1.5601 mL
80 mM 0.0468 mL 0.2340 mL 0.4680 mL 1.1701 mL
100 mM 0.0374 mL 0.1872 mL 0.3744 mL 0.9360 mL
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CRBN ligand-888 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-88853727-25-6CRBN ligand888CRBN ligand 888Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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