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Cat. No.: HY-P12377

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cTP-AlkF-2

cTP-AlkF-2 is a macrocyclic peptide targeting the ganglioside GT1b receptor and can cross the blood-brain barrier. cTP-AlkF-2 induces caveolae-mediated endocytosis/transcytosis, macropinocytosis-mediated internalization, and energy-dependent active transport. cTP-AlkF-2 can serve as a delivery carrier for the synthesis of PVtCD-cTP-AlkF-2 (HY-188196). cTP-AlkF-2 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₁₀₁H₁₄₁F₁₂N₂₅O₂₆S₂
Molecular Weight:2413.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

cTP-AlkF-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Lysosomal MetabolismOxidative StressAβ/Tau/α-Synuclein AggregationProtein/Amino Acid MetabolismOthers

Lysosomal Metabolism

cTP-AlkF-2 internalizes into hCMEC/D3 cells via caveolae-mediated endocytosis and macropinocytosis^[1].
cTP-AlkF-2 (4 °C) is internalized in brain microvascular endothelial cells mainly through caveolae-mediated endocytosis and macropinocytosis^[2].

Oxidative Stress

cTP-AlkF-2 (24 h) is stable at pH 7.4 in the absence of H₂O₂ and undergoes nearly complete decaging upon ROS triggering^[1].

Oxidative Stress

Aβ/Tau/α-Synuclein Aggregation

Protein/Amino Acid Metabolism

cTP-AlkF-2 (10 μM) selectively reduces total DAPK1 by 62% in Aβ42-exposed SH-SY5Y neurons while not affecting phosphorylated DAPK1^[1].

Others

cTP-AlkF-2 (4 h) shows 11.6-fold higher uptake in hCMEC/D3 cells than the unconjugated DAPK1-binding peptide and 5.6-fold higher uptake than the linear shuttle peptide TP^[1].
cTP-AlkF-2 exhibits enhanced uptake by SH-SY5Y neurons and penetrates the endothelial layer of hCMEC/D3/SH-SY5Y spheroids, accumulating in the neuronal core^[1].
cTP-AlkF-2 (5 µM; 4 h) shows 7.71-fold higher uptake in PC12 cells than FITC-TP^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

Molecular Weight 2413.46
Formula C₁₀₁H₁₄₁F₁₂N₂₅O₂₆S₂
SMILES

O=C1C(CC(N1CCC(OCC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(COC(CCN2C(CC(C2=O)SC[C@H](N)C(N3)=O)=O)=O)F)F)F)F)F)F)=O)=O)SC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]3CC4=CNC=N4)=O)CC(C)C)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CO)=O)[C@@H](C)O)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C65)=O)CCCCN)=O)CC7=CC=C(O)C=C7)=O)CCCNC(N)=N)=O)C(N)=O
Sequence

Cys-His-Leu-Asn-Ile-Leu-Ser-Thr-Leu-Trp-Lys-Tyr-Arg-Cys-NH2 (cyclo with ALKF-2)
Sequence Shortening

CHLNILSTLWKYRC-NH2 (cyclo with ALKF-2)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Peng L, et al. Blood-Brain Barrier-Permeable Macrocyclic Chimeras (BmTACs) for Targeted Protein Degradation in the Aging Brain. J Am Chem Soc. 2026;148(38):41137–41150.

[2]. Peng L, et al. A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood-Brain Barrier in Aging Brain. Angewandte Chemie (International ed. in English). 2026 Jan 16;65(3):e20279.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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