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  4. Cyclopropenone probe 1

Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site. Cyclopropenone probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Cyclopropenone probe 1

Cyclopropenone probe 1 Chemical Structure

CAS No. : 2771119-22-1

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Cyclopropenone probe 1 Related Antibodies

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Description

Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site. Cyclopropenone probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cellular Effect
Cell Line Type Value Description References
Bcap37 IC50
45 μM
Compound: CY-1
Antiproliferative activity against human BcaP37 cells assessed as cell viability incubated for 24 hrs by CCk8 assay
Antiproliferative activity against human BcaP37 cells assessed as cell viability incubated for 24 hrs by CCk8 assay
[PMID: 34623802]
MDA-MB-231 IC50
0.78 μM
Compound: CY1
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 36762554]
Molecular Weight

184.19

Formula

C12H8O2
CAS No.
SMILES

C#CCOC1=CC=C(C=C1)C2=CC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclopropenone probe 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclopropenone probe 12771119-22-1Cyclopropenone probe1Cyclopropenone probe-1Biochemical Assay ReagentsInhibitorinhibitorinhibit

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