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Art. -Nr.: HY-184904

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Antimicrobial agent-52

Antimicrobial agent-52 is a broad-spectrum Bactericide. Antimicrobial agent-52 exerts rapid bactericidal effects against Gram-positive and Gram-negative pathogenic bacteria. Antimicrobial agent-52 exhibits activity against Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli. Antimicrobial agent-52 can be used in the research of bacterial infections.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₂₀N₂O₆
Molecular Weight:456.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimicrobial agent-52 Chemical Structure

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Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Antimicrobial agent-52 (Compound 4p) (0.01-25 μM; 24 h) potently inhibits the growth of Staphylococcus aureus (MIC = 0.88 μM), Klebsiella pneumoniae (MIC = 0.15 μM), Acinetobacter baumannii (MIC = 0.76 μM), and Escherichia coli (MIC = 0.02 μM) in vitro^[1].
Antimicrobial agent-52 (24 h) exhibits bactericidal activity in vitro against Staphylococcus aureus (MBC = 1.56 μM), Klebsiella pneumoniae (MBC = 0.19 μM), Acinetobacter baumannii (MBC = 1.56 μM), and Escherichia coli (MBC = 0.04 μM)^[1].

Others

Antimicrobial agent-52 (6.25-200 μM; 24 h) exhibits a CC₅₀ value of 42.27 μM in RAW 264.7 cells, 49.58 μM in J774A.1 cells, and 200 μM in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

RAW 264.7, J774A.1, HEK293
Concentration:

6.25-200 μM
Incubation Time:

20 h (with compound); 4 h (with MTT)
Result:

Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for RAW 264.7 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for J774A.1 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~44%, ~70%, ~87%, ~88%, ~93%, and ~96% for HEK293 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Calculated CC₅₀ values were 42.27 μM for RAW 264.7, 49.58 μM for J774A.1, and 200 μM for HEK293.
Achieved Selectivity Index (SI) values ranging from 48.03 to 2113.5 for RAW 264.7, 56 to 2479 for J774A.1, and 227.27 to 10,000 for HEK293 against the four bacterial strains.

Related Protocols :

Chemical Information

Molecular Weight 456.45
Formel C₂₆H₂₀N₂O₆
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C1C(OCC4=CC(C5=NC=CC=C5)=NO4)=C(OC)C(OC)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Rani D, et al. Design and synthesis of novel baicalein-isoxazoles based scaffolds and their anti-microbial potential: in vitro and in silico evaluation. Bioorganic chemistry. 2026 Jun 26;180:110181. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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