SOSTDC1 - sclerostin domain containing 1 Gene

Also Known as DAND7; USAG1; CDA019; ECTODIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25928

About SOSTDC1

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:16,461,481-16,465,738 (from NCBI)

This gene has 2 transcripts (splice variants), 127 orthologues and 1 paralogue. Biased expression in lung (RPKM 31.5), stomach (RPKM 24.1) and 9 other tissues.

Summary

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]

SOSTDC1 Products (1)

mRNA	Protein	Name
NM_015464.3	NP_056279.1	sclerostin domain-containing protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables BMP binding	IDA IDA: Inferred from direct assay	15020244	GOA
enables BMP receptor activity	IDA IDA: Inferred from direct assay	15020244	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	15020244	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	15020244	GOA
involved in negative regulation of determination of dorsal identity	IDA IDA: Inferred from direct assay	15020244	GOA
involved in negative regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	15020244	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15020244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOSTDC1 Protein Structure

Sclerostin

0
100
206 a.a.

Protein Preferred Names	Protein Names
sclerostin domain-containing protein 1	cystine-knot containing secreted protein

Recombinant SOSTDC1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P78765	USAG-1 Protein, Human (HEK293, Fc)	Q6X4U4-1 (F24-S206)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Renal Fibrosis
Sclerosteosis 1	SOST1 Sost Cortical Hyperostosis With Syndactyly Sclerosteosis Sclerosteosis, Type 1
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13579	SOSTDC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22046	Sostdc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28564	Sostdc1 Rat Pre-designed siRNA Set A		/	Unkown

Inhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P992304	Anti-SOSTDC1 Antibody		/	Unkown
HY-P992311	Anti-USAG-1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SOSTDC1	MGD	MGI:1913292
Felis catus	SOSTDC1	VGNC	VGNC:80722
Canis familiaris	SOSTDC1	VGNC	VGNC:46668
Macaca mulatta	SOSTDC1	VGNC	VGNC:77973
Rattus norvegicus	SOSTDC1	RGD	RGD:628877
Bos taurus	SOSTDC1	VGNC	VGNC:35136
Others	SOSTDC1	NCBI