Prps1 - phosphoribosyl pyrophosphate synthetase 1 Gene

Predicted to enable ATP binding activity; protein homodimerization activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in several processes, including 5-phosphoribose 1-diphosphate biosynthetic process; purine-containing compound biosynthetic process; and urate biosynthetic process. Predicted to act upstream of or within nucleotide biosynthetic process and phosphorylation. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; inner ear; and retina. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]