MOG - myelin oligodendrocyte glycoprotein Gene
Also Known as BTN6; BTNL11; MOGIG2; NRCLP7
Species: Homo sapiens
About MOG
This gene has 19 transcripts (splice variants), 1 gene allele, 173 orthologues, 15 paralogues and is associated with 2 phenotypes. Restricted expression toward brain (RPKM 52.4).
Summary
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
MOG Products (10)
| mRNA | Protein | Name |
|---|---|---|
| NM_001008228.3 | NP_001008229.1 | myelin-oligodendrocyte glycoprotein isoform alpha3 precursor |
| NM_001008229.3 | NP_001008230.1 | myelin-oligodendrocyte glycoprotein isoform beta2 precursor |
| NM_001170418.2 | NP_001163889.1 | myelin-oligodendrocyte glycoprotein isoform alpha6 precursor |
| NM_001363610.2 | NP_001350539.1 | myelin-oligodendrocyte glycoprotein isoform 10 precursor |
| NM_002433.5 | NP_002424.3 | myelin-oligodendrocyte glycoprotein isoform beta1 precursor |
| NM_206809.4 | NP_996532.2 | myelin-oligodendrocyte glycoprotein isoform alpha1 precursor |
| NM_206810.4 | NP_996533.2 | myelin-oligodendrocyte glycoprotein isoform beta5 precursor |
| NM_206811.4 | NP_996534.2 | myelin-oligodendrocyte glycoprotein isoform beta3 precursor |
| NM_206812.4 | NP_996535.2 | myelin-oligodendrocyte glycoprotein isoform alpha2 precursor |
| NM_206814.6 | NP_996537.3 | myelin-oligodendrocyte glycoprotein isoform alpha5 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
MOG Protein Structure
V-set: Immunoglobulin V-set domain (33 - 135)
- 0
- 100
- 200
- 247 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myelin-oligodendrocyte glycoprotein |
|
Recombinant MOG Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70845 | MOG Protein, Human (HEK293, His, solution) | Q16653-1 (G30-G154) | ≥ 95%, as determined by reducing SDS-PAGE. |
MOG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83532 | MOG Antibody (YA3277) | WB, ICC/IF | Rat |
| HY-P83532A | MOG Antibody (YA3277)(PBS only) | WB, ICC/IF | Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Narcolepsy 7 |
|
|
| Rubella |
|
|
| Primary Progressive Multiple Sclerosis |
|
|
| Optic Neuritis |
|
|
| Narcolepsy 1 |
|
|
| Neuromyelitis Optica |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Demyelinating Disease |
|
|
| Subacute Sclerosing Panencephalitis |
|
|
| Sleep Disorder |
|
|
| Autoimmune Optic Neuritis |
|
|
| Multiple Sclerosis |
|
|
| Narcolepsy |
|
|
| Autoimmune Disease Of Peripheral Nervous System |
|
|
| Optic Papillitis |
|
|
| Vascular Myelopathy |
|
|
| Neuritis |
|
|
| Acute Disseminated Encephalomyelitis |
|
|
| Cranial Nerve Disease |
|
|
| Spinal Cord Disease |
|
|
| Balo Concentric Sclerosis |
|
|
| Neurosarcoidosis |
|
|
| Autoimmune Disease |
|
|
| Transverse Myelitis |
|
|
| Adrenoleukodystrophy |
|
|
| Internuclear Ophthalmoplegia |
|
|
| Acute Flaccid Myelitis |
|
|
| Central Nervous System Disease |
|
|
| Acute Retrobulbar Neuritis |
|
|
| Nerve Fibre Bundle Defect |
|
|
| Encephalitis |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Acute Hemorrhagic Leukoencephalitis |
|
|
| Intermittent Proptosis |
|
|
| Acute Necrotizing Encephalitis |
|
|
| Tuberculous Encephalopathy |
|
|
| Guillain-Barre Syndrome |
|
|
| Postinfectious Encephalitis |
|
|
| Neuroretinitis |
|
|
| Partial Optic Atrophy |
|
|
| Nonarteritic Anterior Ischemic Optic Neuropathy |
|
|
| Myelitis |
|
|
| Secondary Progressive Multiple Sclerosis |
|
|
| Optic Nerve Disease |
|
|
| Brachial Plexus Neuritis |
|
|
| Miller Fisher Syndrome |
|
|
| Progressive Relapsing Multiple Sclerosis |
|
|
| Cranial Nerve Palsy |
|
|
| Quadriplegia |
|
|
| Obsessive-Compulsive Disorder |
|
|
| Progressive Multifocal Leukoencephalopathy |
|
|
| Facial Nerve Disease |
|
|
| Facial Paralysis |
|
|
| Acute Dacryoadenitis |
|
|
| West Nile Encephalitis |
|
|
| Autotopagnosia |
|
|
| Papilledema |
|
|
| Demyelinating Polyneuropathy |
|
|
| Aseptic Meningitis |
|
|
| Chickenpox |
|
|
| Intracranial Hypertension, Idiopathic |
|
|
| Abducens Palsy |
|
|
| Nemaline Myopathy 3 |
|
|
| Meningoencephalitis |
|
|
| Viral Encephalitis |
|
|
| Peripheral Nervous System Disease |
|
|
| Pelizaeus-Merzbacher Disease |
|
|
| Schizophrenia |
|
|
| Sarcoid Meningitis |
|
|
| Hypomyelinating Leukodystrophy |
|
|
| Behcet Syndrome |
|
|
| Nervous System Disease |
|
|
| Leber Hereditary Optic Neuropathy, Modifier Of |
|
|
| Strabismus |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | MOG | VGNC | VGNC:57308 |
| Bos taurus | MOG | VGNC | VGNC:57316 |
| Rattus norvegicus | MOG | RGD | RGD:3102 |
| Felis catus | MOG | VGNC | VGNC:68298 |
| Macaca mulatta | MOG | VGNC | VGNC:74909 |
| Mus musculus | MOG | MGD | MGI:97435 |
| Others | MOG | NCBI |