IDH1 Inhibitor 5
IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1940128-37-9
- Formula: C26H34N4O3
- Molecular Weight:450.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)[1]
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Cell Line
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Type | Value | Description | References |
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| MOG-G-UVW | IC50 |
64.4 nM
Compound: 2
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Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
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[PMID: 35450359] |
IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein
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Concentration:0-10 μM
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Incubation Time:1 hour
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Result:Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.
Chemical Information
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CAS No. 1940128-37-9
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Molecular Weight 450.57
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Formula C26H34N4O3
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SMILES
CC(O[C@H]1CC[C@@H](CC1)C(N2CC3=C(NC4=C2C=C(C=C4)N5CCOCC5)N=CC=C3)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDH1 Inhibitor 5 Related Classifications
HY-143306 Related Classifications
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