2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. IDH1 Inhibitor 5

IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.

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IDH1 Inhibitor 5 Chemical Structure

IDH1 Inhibitor 5 Chemical Structure

CAS No. : 1940128-37-9

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IDH1 Inhibitor 5 Related Antibodies

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Description

IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively[1].

IC50 & Target

IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)[1]
In Vitro

IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDH1 Inhibitor 5 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.
Molecular Weight

450.57

Formula

C26H34N4O3
CAS No.
SMILES

CC(O[C@H]1CC[C@@H](CC1)C(N2CC3=C(NC4=C2C=C(C=C4)N5CCOCC5)N=CC=C3)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IDH1 Inhibitor 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDH1 Inhibitor 51940128-37-9Isocitrate Dehydrogenase (IDH)tricyclic diazepineGSH-adductanticancer2-HG reductionMOGexogenous mutantR132HInhibitorinhibitorinhibit

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