1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)
  3. IDH1 Inhibitor 5

IDH1 Inhibitor 5 

Cat. No.: HY-143306
Handling Instructions

IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.

For research use only. We do not sell to patients.

IDH1 Inhibitor 5 Chemical Structure

IDH1 Inhibitor 5 Chemical Structure

CAS No. : 1940128-37-9

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Description

IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively[1].

IC50 & Target

IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)[1]

In Vitro

IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.
Molecular Weight

450.57

Formula

C26H34N4O3

CAS No.
SMILES

CC(O[[email protected]]1CC[[email protected]@H](CC1)C(N2CC3=C(NC4=C2C=C(C=C4)N5CCOCC5)N=CC=C3)=O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
IDH1 Inhibitor 5
Cat. No.:
HY-143306
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