PI3Kδ-IN-21
PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC50 of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model.
For research use only. We do not sell to patients.
- CAS No.: 3048633-11-7
- Formula: C19H16ClN9
- Molecular Weight:405.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kδ 13.6 nM (IC50) |
PI3Kβ 1660 nM (IC50) |
PI3Kα 7034 nM (IC50) |
Chemical Information
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CAS No. 3048633-11-7
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Molecular Weight 405.84
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Formula C19H16ClN9
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SMILES
C[C@@H](C1=CN(C2=CC(Cl)=CN=C21)C3=CC=CN=C3)NC4=NC(N)=NC(N)=C4C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3Kδ-IN-21 Related Classifications
HY-158688 Related Classifications
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