F2RL3 - F2R like thrombin or trypsin receptor 3 Gene

Also Known as PAR4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9002

About F2RL3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,888,999-16,892,606 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 16 paralogues. Broad expression in fat (RPKM 1.9), stomach (RPKM 1.3) and 16 other tissues.

Summary

This gene encodes a member of the Protease-activated Receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung Cancer in human patients. [provided by RefSeq, Sep 2016]

F2RL3 Products (1)

mRNA Protein Name
NM_003950.4 NP_003941.2 proteinase-activated receptor 4 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protease binding IPI
IPI: Inferred from physical interaction
18434511 GOA
Biological Process GO Annotation Evidence References Source
involved in platelet activation IDA
IDA: Inferred from direct assay
10702240 GOA
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
18480058 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2RL3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (95 - 340)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
Protein Preferred Names Protein Names

proteinase-activated receptor 4

  • F2R like thrombin/trypsin receptor 3

  • PAR-4

  • coagulation factor II (thrombin) receptor-like 3

  • protease-activated receptor-4

  • thrombin receptor-like 3

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Protection Against

  • Lung Cancer, Susceptibility To

  • Adenocarcinoma Of Lung, Somatic

  • Nonsmall Cell Lung Cancer

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04640 F2RL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04641 F2rl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04642 F2rl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus F2RL3 VGNC VGNC:28686
Mus musculus F2RL3 MGD MGI:1298207
Canis familiaris F2RL3 VGNC VGNC:40550
Felis catus F2RL3 VGNC VGNC:62025
Rattus norvegicus F2RL3 RGD RGD:620872
Others F2RL3 NCBI