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Cat. No.: HY-D3394

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SGC5

SGC5 is a fluorescence enhancer and membrane dissociator with millisecond-scale membrane dissociation kinetics, with an emission spectrum of 500-650 nm. SGC5 produces strong fluorescence upon binding to lipid membranes, exhibits fast partitioning dissociation kinetics at higher temperatures, and is unaffected by pH or cholesterol. SGC5 does not belong to the FM dye family and shows the highest membrane-bound fluorescence intensity among the tested styryl/FM dyes. SGC5 can be used to study synaptic vesicle cycling in neurons.

For research use only. We do not sell to patients.

CAS No.: 1331918-67-2
Formula: C₃₃H₅₁Br₂N₃O₂
Molecular Weight:681.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SGC5 Chemical Structure

CAS No.: 1331918-67-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vitro

When SGC5 (0-20 μM) binds to 30% PE/70% PC liposomes, its fluorescence intensity is higher than that of all tested FM dyes, and the fold increase in fluorescence after membrane binding is second only to that of FM1-84^[1].
SGC5 (0-20 nM liposomes; fixed SGC5 concentration) binds to 30% PE/70% PC liposomes with an EC₅₀ of 4.0 nM, and the resulting fluorescence intensity and signal-to-noise ratio are comparable to those of FM1-84 (HY-D1515) and FM1-43 (HY-D1434)^[1].
After being loaded into synaptic vesicles of cultured rat hippocampal neurons, SGC5 (2 μM; 3 min) emits a peak at ~530 nm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1331918-67-2
Molecular Weight 681.58
Formula C₃₃H₅₁Br₂N₃O₂
SMILES

CC[N+](CCC[N+]1=CC=C(C(C2=O)=CC3=C(O2)C=C(N(CCCCC)CCCCC)C=C3)C=C1)(CC)CC.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu Y, et al. Biophysical characterization of styryl dye-membrane interactions[J]. Biophysical journal, 2009, 97(1): 101-109.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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