Deferoxamine-DBCO
Based on 1 Customer Validation
Deferoxamine-DBCO (DFO-DBCO) is a bifunctional small-molecule synthetic building block obtained by covalent conjugation of the DFO metal-chelating group with DBCO, and is a bifunctional chelator. Deferoxamine-DBCO efficiently chelates radioactive metals (such as 89Zr) through the DFO moiety to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA and monoclonal antibodies) through the DBCO moiety under bioorthogonal conditions to accomplish targeted conjugation. Deferoxamine-DBCO is applicable to research related to bioconjugation chemistry and the preparation of PET radiotracer probes.
For research use only. We do not sell to patients.
- Purity : 89.08%
- CAS No.: 2359695-48-8
- Formula: C44H61N7O10
- Molecular Weight:848.00
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
Description
IC50 & Target
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RDC Bifunctional Chelator |
In Vitro
Deferoxamine-DBCO (DFO-DBCO) reacts with azide-modified antibody glycosylation sites via SPAAC copper-free click chemistry; after bioconjugation, it chelates the 89Zr radionuclide to construct PET/NIRF dual-modality radioimmunoconjugates[1].
Deferoxamine-DBCO (DFO-DBCO) reacts with azide-functionalized ultrasmall C' dots silica nanoparticles via SPAAC copper-free click chemistry, introducing 89Zr chelating groups onto the nanoparticle surface[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2359695-48-8
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Appearance Solid
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Molecular Weight 848.00
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Formula C44H61N7O10
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Color White to yellow
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SMILES
CC(N(CCCCCNC(CCC(N(CCCCCNC(CCC(N(CCCCCNC(CCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O)=O)O)=O)=O)O)=O)=O)O)=O
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Synonyms
DFO-DBCO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (117.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1792 mL | 5.8962 mL | 11.7925 mL | 29.4811 mL |
| 5 mM | 0.2358 mL | 1.1792 mL | 2.3585 mL | 5.8962 mL | |
| 10 mM | 0.1179 mL | 0.5896 mL | 1.1792 mL | 2.9481 mL | |
| 15 mM | 0.0786 mL | 0.3931 mL | 0.7862 mL | 1.9654 mL | |
| 20 mM | 0.0590 mL | 0.2948 mL | 0.5896 mL | 1.4741 mL | |
| 25 mM | 0.0472 mL | 0.2358 mL | 0.4717 mL | 1.1792 mL | |
| 30 mM | 0.0393 mL | 0.1965 mL | 0.3931 mL | 0.9827 mL | |
| 40 mM | 0.0295 mL | 0.1474 mL | 0.2948 mL | 0.7370 mL | |
| 50 mM | 0.0236 mL | 0.1179 mL | 0.2358 mL | 0.5896 mL | |
| 60 mM | 0.0197 mL | 0.0983 mL | 0.1965 mL | 0.4914 mL | |
| 80 mM | 0.0147 mL | 0.0737 mL | 0.1474 mL | 0.3685 mL | |
| 100 mM | 0.0118 mL | 0.0590 mL | 0.1179 mL | 0.2948 mL |
Deferoxamine-DBCO Related Classifications
HY-158067 Related Classifications
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Keywords
- Deferoxamine-DBCO
- 2359695-48-8
- DFO-DBCO
- Biochemical Assay Reagents
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