1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Dihydro-β-erythroidine hydrobromide

Dihydro-β-erythroidine hydrobromide (Synonyms: DHβE hydrobromide)

Cat. No.: HY-107670
Handling Instructions

IC50: 0.19 μM (α4β4); 0.37 μM (α4β2); 0.41 μM (α3β2); 1.3 μM (α2β2); 2.3 μM (α2β4); 23.1 μM (α3β4)

Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active and competitive antagonist of neuronal nicotinic acetyicholine receptors (nAChRs). Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities.

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Dihydro-β-erythroidine hydrobromide Chemical Structure

Dihydro-β-erythroidine hydrobromide Chemical Structure

CAS No. : 29734-68-7

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Description

Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active and competitive antagonist of neuronal nicotinic acetyicholine receptors (nAChRs). Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities[1][2][3].

In Vivo

Dihydro-Beta-Erythroidine hydrobromide (DHβE hydrobromide; 10 nmol/0.5 μL) is infused into the respective areas prior to a systemic nicotine injection (0.2 mg/kg; SC). DHβE infused into the ventral tegmental area (VTA), nucleus accumbens (NAcc), or infralimbic (IL) cortex, but not prelimbic (PrL) cortex, attenuated nicotine-enhanced responding for a conditioned reinforcer (CRf)[2].
The co-administration of Dihydro-Beta-Erythroidine hydrobromide (5.0 mg/kg; s.c) with nicotine (0.2 and 0.4 mg/kg; s.c.) prevents the development of conditioned taste aversions (CTAs)[4].

Animal Model: Male hooded Lister rats[4]
Dosage: 0.5, 1.6 and 5.0 mg/kg
Administration: S.c.
Result: A complete blockade of the nicotine effect produced by the training dose of nicotine (0.2 mg/kg).
Molecular Weight

356.25

Formula

C₁₆H₂₂BrNO₃

CAS No.

29734-68-7

SMILES

CO[[email protected]@H]1C[[email protected]]23C(CC4=O)=C(CO4)CCN2CCC3=CC1.Br

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Dihydro-β-erythroidineDHβEnAChRNicotinic acetylcholine receptorsantidepressantnicotinecompetitivebehavioralErythrinaalkaloidsoralInhibitorinhibitorinhibit

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Dihydro-β-erythroidine hydrobromide
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