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  4. Dimethyl succinate

Dimethyl succinate is an orally active cell permeable succinate analogue. Dimethyl succinate can disrupt the TCA cycle by elevating intracellular succinate levels, leading to reduced protein synthesis and impairs myogenic differentiation. Dimethyl succinate can induce apoptosis. Dimethyl succinate can decrease maximal cellular respiration and reserve capacity. Dimethyl succinate can rescue synapse loss in AD. Dimethyl succinate can be used for the researches of metabolic and neurological disease[1][2].

For research use only. We do not sell to patients.

CAS No. : 106-65-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Dimethyl succinate:

Dimethyl succinate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dimethyl succinate

Flow Cytometry

    Dimethyl succinate purchased from MedChemExpress. Usage Cited in: Chin Med. 2024 May 13;19(1):68.  [Abstract]

    Dimethyl succinate (DES) (5 mM; 72 h) reversed the decrease of CD44 expression and proliferation of CD4+ T cells by acacetin.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Dimethyl succinate is an orally active cell permeable succinate analogue. Dimethyl succinate can disrupt the TCA cycle by elevating intracellular succinate levels, leading to reduced protein synthesis and impairs myogenic differentiation. Dimethyl succinate can induce apoptosis. Dimethyl succinate can decrease maximal cellular respiration and reserve capacity. Dimethyl succinate can rescue synapse loss in AD. Dimethyl succinate can be used for the researches of metabolic and neurological disease[1][2].

    In Vitro

    Dimethyl succinate (16 mM) increases apoptotic cells in C2C12 myoblasts[1].
    Dimethyl succinate (4-8 mM, 48 h) increases intracellular succinate, malate and glutamate in C2C12 myoblasts[1]. Dimethyl succinate (8 mM, 48 h) reduces protein anabolism as determined by an O-propargyl-puromycin (OPP) incorporation assay in C2C12 myoblasts[1]. Dimethyl succinate (8 mM) reduces maximal respiration and mitochondria reserve capacity in C2C12 myoblasts[1]. Dimethyl succinate (8 mM) results in an impaired ability to form mature, multinucleated Myosin Heavy Chain-positive structures in C2C12 myoblasts[1]. Dimethyl succinate (5 mM, 48 h) partially rescues synapse loss in AD hiPSC-derived cerebrocortical neurons[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Dimethyl succinate Related Antibodies

    Cell Proliferation Assay[1]

    Cell Line: C2C12 myoblasts
    Concentration: 4 mM, 8 mM, 16 mM
    Incubation Time: 48 hours
    Result: Showed no significant differences in proliferation over this time period.

    Apoptosis Analysis[1]

    Cell Line: C2C12 myoblasts
    Concentration: 4 mM, 8 mM, 16 mM
    Incubation Time: 48 hours
    Result: Only increased apoptosis rates at 16 mM.
    In Vivo

    Dimethyl succinate (2% in water, p.o., 6 weeks) impairs skeletal muscle homeostasis and regeneration, leading to smaller muscle myofiber diameters[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: FVB mice; wild type model[1]
    Dosage: 2% in water
    Administration: Oral; 6 weeks
    Result: Had no significant difference in total body weight and total lean mass.
    Impaired skeletal muscle homeostasis and regeneration.
    Exhibited smaller muscle myofiber diameters.
    Molecular Weight

    146.14

    Formula

    C6H10O4
    CAS No.
    Appearance

    <16°C Solid,>19°C Liquid

    Color

    Colorless to off-white

    SMILES

    O=C(OC)CCC(OC)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 200 mg/mL (1368.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 100 mg/mL (684.28 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.8428 mL 34.2138 mL 68.4275 mL
    5 mM 1.3686 mL 6.8428 mL 13.6855 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  Saline

      Solubility: ≥ 100 mg/mL (684.28 mM); Clear solution

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

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    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.95%

    SDS (393 KB)

    COA (244 KB) HNMR (127 KB) GC (209 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 6.8428 mL 34.2138 mL 68.4275 mL 171.0688 mL
    5 mM 1.3686 mL 6.8428 mL 13.6855 mL 34.2138 mL
    10 mM 0.6843 mL 3.4214 mL 6.8428 mL 17.1069 mL
    15 mM 0.4562 mL 2.2809 mL 4.5618 mL 11.4046 mL
    20 mM 0.3421 mL 1.7107 mL 3.4214 mL 8.5534 mL
    25 mM 0.2737 mL 1.3686 mL 2.7371 mL 6.8428 mL
    30 mM 0.2281 mL 1.1405 mL 2.2809 mL 5.7023 mL
    40 mM 0.1711 mL 0.8553 mL 1.7107 mL 4.2767 mL
    50 mM 0.1369 mL 0.6843 mL 1.3686 mL 3.4214 mL
    60 mM 0.1140 mL 0.5702 mL 1.1405 mL 2.8511 mL
    80 mM 0.0855 mL 0.4277 mL 0.8553 mL 2.1384 mL
    100 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.7107 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Dimethyl succinate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dimethyl106-65-0Environmental PollutantsApoptosisEnvironmental Contaminantsdimethyl succinatetricarboxylic acid cyclesapoptosissuccinatemaximal cellular respirationreserve capacitysynapseADmetabolicneurologicalC2C12 myoblastsInhibitorinhibitorinhibit

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