Daxdilimab
Based on 1 Customer Validation
Daxdilimab (MEDI7734; VIB7734) is a monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes plasmacytoid dendritic cells and reduces IFN1 production by binding to the plasmacytoid dendritic cell-specific surface molecule ILT7 and recruiting effector natural killer cells. Daxdilimab (MEDI7734; VIB7734) can be used for research on systemic lupus erythematosus, systemic sclerosis, and polymyositis.
For research use only. We do not sell to patients.
- Purity : 97.82%
- CAS No.: 2245966-28-1
- Molecular Weight:144.38 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
ILT7 |
IFN1 |
In Vitro
Daxdilimab (MEDI7734; VIB7734) (10-4 to 103 relative value; IC50-corrected) has an IC50 of 8.4 ng/mL and achieves 34% maximal IFNGS inhibition at typical parameter values[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 lambda2
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized LILRA4/ILT-7/CD85g Protein, Human (HEK293, His, HY-P77441) can bind Daxdilimab. The EC50 for this effect is 641.3 ng/mL.
Chemical Information
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CAS No. 2245966-28-1
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Appearance Liquid
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Molecular Weight 144.38 kDa
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Color Colorless to light yellow
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SMILES
[Daxdilimab]
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Synonyms
MEDI7734; VIB7734
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Daxdilimab
- 2245966-28-1
- MEDI7734
- VIB7734
- MEDI 7734
- MEDI-7734
- VIB7734
- VIB 7734
- VIB-7734
- Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
- IFNAR
- immunoglobulin-like transcript 7
- IFN1
- type I interferon
- dermatomyositis
- plasmacytoid dendritic cells
- cutaneous lupus erythematosus
- systemic sclerosis
- systemic lupus erythematosus
- natural killer cells
- ILT7
- Inhibitor
- inhibitor
- inhibit