FTI-249
FTI-249 is a farnesyl transferase inhibitor with an IC50 of 100-200 nM. FTI-249 acts as a linear competitive inhibitor targeting the peptide substrate of farnesyl transferase. FTI-249 is applicable for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 161721-65-9
- Formula: C15H23N3O3S2
- Molecular Weight:357.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FTI-249 (100 nM; up to 50 min) acts as a classical linear competitive inhibitor of recombinant rat FTase, producing linear product formation kinetics when used at 100 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 161721-65-9
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Molecular Weight 357.49
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Formula C15H23N3O3S2
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SMILES
CSCC[C@@H](C(O)=O)NC(C1=CC=C(C=C1)NC[C@@H](N)CS)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sebti SM, et al. Inhibition of Ras prenylation: a novel approach to cancer chemotherapy. Pharmacology & therapeutics. 1997;74(1):103-14. [Content Brief]
[2]. Roskoski R, et al. Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic. Biochemistry. 2001 Aug 07;40(31):9329-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTI-249 Related Classifications
HY-117524 Related Classifications
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